| Genotype | Overall | Men | Women | ||||||
| Cases No | Controls No | OR (95% CI) | Cases No | Controls No | OR (95% CI) | Cases No | Controls No | OR (95% CI) | |
| MLH1 -93G>A | |||||||||
| GG | 952 | 1170 | 1 (referent) | 542 | 633 | 1 (referent) | 410 | 537 | 1 (referent) |
| GA | 553 | 688 | 1.00 (0.87 to 1.16) | 295 | 349 | 1.00 (0.83 to 1.22) | 258 | 339 | 0.99 (0.81 to 1.22) |
| AA | 95 | 105 | 1.12 (0.84 to 1.51) | 58 | 58 | 1.19 (0.81 to 1.75) | 37 | 47 | 1.03 (0.66 to 1.63) |
| MLH1 Ile219Val (655A>G) | |||||||||
| Ile/Ile | 764 | 937 | 1 (referent) | 403 | 496 | 1 (referent) | 361 | 441 | 1 (referent) |
| Ile/Val | 678 | 843 | 1.00 (0.87 to 1.15) | 397 | 448 | 1.11 (0.91 to 1.34) | 281 | 395 | 0.89 (0.72 to 1.09) |
| Val/Val | 159 | 187 | 1.05 (0.83 to 1.33) | 96 | 97 | 1.22 (0.89 to 1.68) | 63 | 90 | 0.87 (0.61 to 1.25) |
| MLH1 -93G>A/Ile219Val† | |||||||||
| GG and Ile/Ile | 352 | 410 | 1 (referent) | 186 | 218 | 1 (referent) | 166 | 192 | 1 (referent) |
| GA and Ile/Ile | 317 | 421 | 0.90 (0.73 to 1.11) | 159 | 219 | 0.88 (0.66 to 1.17) | 158 | 202 | 0.91 (0.68 to 1.23) |
| GG and Ile/Val | 441 | 574 | 0.92 (0.76 to 1.11) | 260 | 319 | 0.99 (0.76 to 1.28) | 181 | 255 | 0.85 (0.64 to 1.13) |
| GA and Ile/Val | 236 | 266 | 1.07 (0.85 to 1.35) | 136 | 129 | 1.29 (0.94 to 1.76) | 100 | 137 | 0.87 (0.62 to 1.21) |
| AA and Ile/Ile | 95 | 105 | 1.08 (0.79 to 1.48) | 58 | 58 | 1.22 (0.80 to 1.85) | 37 | 47 | 0.93 (0.58 to 1.51) |
| GG and Val/Val | 159 | 187 | 1.01 (0.78 to 1.31) | 96 | 97 | 1.19 (0.84 to 1.68) | 63 | 90 | 0.84 (0.57 to 1.23) |
| MSH6 Gly39Glu (116G>A) | |||||||||
| Gly/Gly | 1037 | 1340 | 1 (referent) | 580 | 724 | 1 (referent) | 457 | 616 | 1 (referent) |
| Gly/Glu | 514 | 557 | 1.19 (1.03 to 1.38) | 283 | 277 | 1.28 (1.05 to 1.56) | 231 | 280 | 1.11 (0.90 to 1.38) |
| Glu/Glu | 48 | 62 | 0.99 (0.67 to 1.46) | 31 | 33 | 1.15 (0.69 to 1.91) | 17 | 29 | 0.81 (0.44 to 1.51) |
| Gly/Glu or Glu/Glu | 562 | 619 | 1.17 (1.02 to 1.35) | 314 | 310 | 1.27 (1.04 to 1.54) | 248 | 309 | 1.09 (0.88 to 1.34) |
*Adjusted for age, sex, race, centre and usual amount smoked (cigarettes/day); observations vary slightly from table 1 due to missing data.
†Combined genotypes GA and Val/Val, AA and Ile/Val, and AA and Val/Val were not observed in the study population.