Table 3 Risk of colon cancer associated with mismatch repair genotype, by microsatellite instability (MSI) status*
GenotypeMSI-positive tumoursMSI-negative tumours
Cases NoControls NoOR (95% CI)p TrendCases NoControls NoOR (95% CI)p Trend
MLH1 -93G>A
    GG10411701 (referent)0.0161611701 (referent)0.61
    GA676881.10 (0.79 to 1.52)3456880.96 (0.82 to 1.14)
    AA221052.47 (1.48 to 4.11)511050.94 (0.66 to 1.34)
MLH1 Ile219Val (655A>G)
    Ile/Ile1009371 (referent)0.194809371 (referent)0.43
    Ile/Val808430.92 (0.67 to 1.25)4248431.00 (0.85 to 1.17)
    Val/Val131870.62 (0.35 to 1.18)1081871.16 (0.89 to 1.51)
MSH6 Gly39Glu (116G>A)
    Gly/Gly12113401 (referent)0.2765513401 (referent)0.13
    Gly/Glu675571.30 (0.95 to 1.79)3265571.19 (1.00 to 1.41)
    Glu/Glu5620.88 (0.35 to 2.25)30620.96 (0.61 to 1.51)
  • *Adjusted for age, sex, race, centre and usual amount smoked (cigarettes/day).