Table 5 Risk of colon cancer associated with mismatch repair genotype, by Western diet pattern*
ExposureWestern diet tertile 1Western diet tertile 2Western diet tertile 3p Interaction
GenotypeCases NoControls NoOR (95% CI)Cases NoControls NoOR (95% CI)Cases NoControls NoOR (95% CI)
MLH1 -93G>A
    GG2304061 (referent)3233961.45 (1.16 to 1.80)3993681.83 (1.47 to 2.28)0.16
    GA1372281.07 (0.82 to 1.40)1992181.61 (1.25 to 2.08)2172421.56 (1.22 to 2.01)
    AA32321.72 (1.02 to 2.90)32361.65 (0.99 to 2.73)31371.44 (0.86 to 2.39)
MLH1 Ile219Val (655A>G)
    Ile/Ile1933111 (referent)2563051.36 (1.06, 1.74)3153211.54 (1.21 to 1.96)0.03
    Ile/Val1752791.02 (0.79 to 1.33)2452811.43 (1.11 to 1.83)2582831.44 (1.12 to 1.85)
    Val/Val31770.66 (0.42 to 1.05)53641.37 (0.91 to 2.06)75462.47 (1.63 to 3.74)
MSH6 Gly39Glu (116G>A)
    Gly/Gly2414501 (referent)3624371.56 (1.27 to 1.93)4344531.71 (1.39 to 2.12)0.45
    Gly/Glu1411951.35 (1.03 to 1.77)1781891.74 (1.34 to 2.26)1951732.04 (1.57 to 2.65)
    Glu/Glu16191.54 (0.78, 3.07)13231.01 (0.50 to 2.05)19201.74 (0.91 to 3.35)
  • *Adjusted for age, sex, race, centre and amount smoked (cigarettes/day). Adjusting for long-term alcohol or body mass index did not affect the estimates.

  • See Slattery et al23 24 for additional descriptions of the Western diet pattern.