Abstract 81 Effects of tyrosine kinase inhibitors (TKIs) on proliferation and apoptosis in gastro-oesophageal cell lines
Cell lineMost active RTKTKI targetSensitivityProliferation IC50Caspase activity increase
HSC39FGFR2FGFR2Highly sensitive5.9nM5 fold
KATO IIIFGFR2FGFR2Sensitive5.3nM1.5 fold
OACM5.1PDGFRaPDGFRaHighly sensitive15nM2 fold
OE19ErbB2LapatinibHighly sensitive43nM6 fold
MKN45MetMetSensitive6.0nM1.5 fold
OE33ErbB2, MetLapa’b-Met CombHighly sensitive54nM3 fold