Table 1 Summary of the association results in our screening (Dutch) and replication (North American and Italian) cohorts, as well as the combined results following the Cochran–Mantel–Haenszel meta-analysis
SNPA1A2Dutch IBD: 1590 cases, 929 controlsNorth American IBD: 2387 cases, 1266 controlsItalian IBD: 805 cases, 421 controlsMeta analysis
MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)Combined p value
rs13151961GA0.190.150.000390.85 (0.71 to 1.02)0.170.140.00020.78 (0.68 to 0.89)0.160.120.00070.66 (0.52 to 0.84)1.41×109
rs13119723GA0.160.130.000930.76 (0.65 to 0.89)0.160.130.00050.78 (0.68 to 0.90)0.170.120.00280.70 (0.55 to 0.89)1.32×108
rs6840978TC0.220.180.000670.78 (0.67 to 0.90)0.210.170.00060.81 (0.71 to 0.91)0.200.160.01600.77 (0.62 to 0.95)6.17×108
rs6822844TG0.190.150.000700.77 (0.66 to 0.89)0.170.140.00050.79 (0.69 to 0.90)0.160.110.00050.65 (0.51–0.83)7.45×106
SNPA1A2Dutch CD: 777 cases, 929 controlsNorth American CD: 654 cases, 1266 controlsItalian CD: 157 cases, 421 controlsMeta analysis
MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)Combined p value
rs13151961GA0.190.170.07610.85 (0.71 to 1.02)0.170.150.01230.79 (0.65 to 0.95)0.160.140.34540.84 (0.58 to 1.21)0.0016
rs13119723GA0.160.140.03270.81 (0.67 to 0.98)0.160.120.00110.72 (0.59 to 0.88)0.170.140.34950.84 (0.58 to 1.21)9.86×10−5
rs6840978TC0.220.200.14540.88 (0.75 to 1.04)0.210.160.00630.76 (0.64 to 0.90)0.200.180.32090.84 (0.60 to 1.18)0.0007
rs6822844TG0.190.160.12210.87 (0.73 to 1.04)0.170.140.00200.77 (0.64 to 0.93)0.160.120.08730.71 (0.48 to 1.05)0.0009
SNPA1A2Dutch UC: 813 cases, 929 controlsNorth American UC: 1733 cases, 1266 controlsItalian UC: 648 cases, 421 controlsMeta analysis
MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)MAF controlsMAF casesp ValueOR (95% CI)Combined p value
rs13151961GA0.190.140.000030.67 (0.56 to 0.81)0.170.140.00040.77 (0.67 to 0.89)0.160.110.00020.62 (0.48–0.80)1.35×10−10
rs13119723GA0.160.120.000380.71 (0.58 to 0.86)0.160.130.00460.81 (0.70 to 0.94)0.170.120.00130.67 (0.52 to 0.85)8.60×10−8
rs6840978TC0.220.160.000010.68 (0.57 to 0.81)0.210.180.00400.83 (0.73 to 0.94)0.200.160.01230.75 (0.60 to 0.94)3.07×10−8
rs6822844TG0.190.130.000040.68 (0.57 to 0.82)0.170.140.00180.80 (0.69 to 0.92)0.160.110.00050.64 (0.49 to 0.82)2.77×10−9
  • Original Dutch cohort (1590 IBD (777 CD, 813 UC), 929 controls), replication cohorts: North American (2387 IBD (553 CD, 1733 UC), 1266 controls); Italian (805 IBD (157 CD, 648 UC), 421 controls). All p values are two-tailed.

  • CD, Crohn’s disease; IBD, inflammatory bowel disease; MAF, minor alllele frequency; SNP, single nucleotide polymorphism; UC, ulcerative colitis.