Results of univariate analysis for predictors of clinical remission and colectomy
Clinical remission | Colectomy | |||
OR (95% CI) | p Value | OR (95% CI) | p Value | |
Female gender | 0.74 (0.34 to 1.59) | 0.57 | 0.81 (0.39 to 1.72) | 0.73 |
Age | 1.62 (0.75 to 3.52) | 0.29 | 0.47 (0.22 to 1.02) | 0.85 |
Pancolitis | 1.23 (0.48 to 3.16) | 0.85 | 1.56 (0.61 to 3.97) | 0.49 |
Disease duration | 0.99 (0.41 to 2.42) | 0.83 | 0.58 (0.25 to 1.37) | 0.31 |
Baseline Mayo score ⩾10 | 0.36 (0.15 to 0.83) | 0.028 | 3.42 (1.56 to 7.51) | 0.004 |
Prednisone ⩾1 year preinfliximab | 0.40 (0.14 to 1.17) | 0.45 | 1.68 (0.69 to 4.15) | 0.38 |
Concurrent immunosuppression | 1.16 (0.47 to 2.88) | 0.92 | 1.13 (0.46 to 2.75) | 0.96 |
Baseline CRP >5 mg/l | 0.60 (0.21 to 1.69) | 0.48 | 1.94 (0.65 to 5.81) | 0.35 |
pANCA positive | 0.89 (0.36 to 2.16) | 0.79 | 0.58 (0.25 to 1.33) | 0.28 |
Antibodies to infliximab | 0.15 (0.06 to 0.40) | <0.001 | 2.71 (1.22 to 6.01) | 0.023 |
Detectable trough serum infliximab | 12.0 (4.76 to 30.26) | <0.001 | 0.13 (0.05 to 0.35) | <0.001 |
Values in bold are statistically significant with a p value <0.05.
CRP, C-reactive protein; pANCA, perinuclear antineutrophil cytoplasmic antibody.