Curcumin effects on bile flow and composition in wild type and Mdr2−/− mice
Variable | WT | WT+Cu | Mdr2−/− | Mdr2−/−+Cu |
Bile flow (μl/g LW/min) | 1.3±0.2 | 1.7±0.2‡ | 1.2±0.2 | 1.8±0.2† |
Bile acids (nmol/g LW/min) | 28.1±6.5 | 38.2±10.1 | 27.4±1.7 | 30.1±14.4 |
Cholesterol (nmol/g LW/min) | 0.6±0.2 | 0.6±0.1 | 0.1±0.0* | 0.2±0.0* |
Glutathione (nmol/g LW/min) | 4.0±0.7 | 8.4±1.4‡ | 1.2±0.3* | 4.9±1.1† |
Phospholipids (nmol/g LW/min) | 4.5±0.7 | 4.7±1.1 | 0.3±0.1* | 0.5±0.1* |