Table 2

Non-steroidal anti-inflammatory drug (NSAID) intake variables and the risk of colorectal cancer: crude and adjusted ORs (95% CI) in the whole sample from logistic regression models

Medicine category	Categories	Numbers		Crude analysis		Adjusted analysis^*
Medicine category	Intake	Cases	Controls	OR	95% CI	OR	95% CI
Any NSAID	No	1602	1852	1.00		1.00
	Yes	648	1025	0.73	0.65, 0.82	0.73	0.64, 0.83
				p=2.4×10⁻⁷		p=2.6×10⁻⁶
75 mg aspirin^†	No	1602	1852	1.00		1.00
	Yes	354	526	0.78	0.67, 0.90	0.78	0.65, 0.92
				p=0.001		p=0.004
Non-aspirin (NA)-NSAIDS	No	1602	1852	1.00		1.00
	Yes	241	385	0.72	0.61, 0.86	0.74	0.60, 0.90
				p=0.0002		p=0.003
NA-NSAIDS and 75 mg aspirin	No	1602	1852	1.00		1.00
	Yes	53	114	0.54	0.38, 0.75	0.47	0.31, 0.70
				p=0.0002		p=0.0003
Dose effect	mg/week	Cases	Controls	OR	95% CI	OR	95% CI
75 mg aspirin	0	1602	1852	1.00		1.00
	≤525	293	439	0.77	0.66, 0.91	0.79	0.66, 0.95
	>525	33	62	0.61	0.40, 0.94	0.66	0.41, 1.05
				p for trend 0.0002		p for trend 0.004
Any aspirin	0	1602	1852	1.00		1.00
	≤525	293	439	0.77	0.66, 0.91	0.79	0.66, 0.95
	525–1050	33	58	0.66	0.43, 1.01	0.69	0.43, 1.11
	>1050	11	19	0.67	0.32, 1.41	0.73	0.33, 1.60
				p for trend 0.0003		p for trend 0.006
Duration	Years	Cases	Controls	OR	95% CI	OR	95% CI
Any NSAID	0	1602	1852	1.00		1.00
	>0 & ≤1	170	245	0.80	0.65, 0.99	0.82	0.66, 1.03
	>1 & ≤3	129	195	0.76	0.61, 0.96	0.78	0.61, 1.01
	>3 & ≤5	80	151	0.61	0.46, 0.81	0.68	0.50, 0.91
	>5 & ≤10	105	215	0.56	0.44, 0.72	0.57	0.44, 0.75
	>10	89	153	0.67	0.51, 0.88	0.71	0.53, 0.95
				p for trend 1.9×10⁻⁹		p for trend 1.1×10⁻⁶
75 mg aspirin	0	1602	1852	1.00		1.00
	>0 & ≤1	53	78	0.79	0.55, 1.12	0.87	0.59, 1.28
	>1 & ≤3	72	96	0.87	0.63, 1.18	0.84	0.59, 1.18
	>3 & ≤5	51	91	0.65	0.46, 0.92	0.75	0.52, 1.08
	>5 & ≤10	71	125	0.66	0.49, 0.88	0.63	0.45, 0.87
	>10	62	101	0.71	0.51, 0.98	0.82	0.58, 1.16
				p for trend 0.00007		p for trend 0.004
Cumulative (75 mg aspirin tablet-years)	0	1602	1852	1.00		1.00
	>0 & ≤1	46	70	0.76	0.52, 1.11	0.83	0.55, 1.25
	>1 & ≤3	69	97	0.82	0.60, 1.13	0.81	0.58, 1.14
	>3 & ≤5	46	81	0.66	0.45, 0.95	0.76	0.51, 1.12
	>5 & ≤10	75	119	0.73	0.54, 0.98	0.69	0.50, 0.96
	>10	66	121	0.63	0.46, 0.86	0.73	0.52, 1.01
				p for trend 0.00003		p for trend 0.002
NA-NSAIDS	0 y	1602	1852	1.00		1.00
	>0 & ≤1	108	158	0.79	0.61, 1.02	0.79	0.60, 1.03
	>1 & ≤3	50	79	0.73	0.51, 1.05	0.81	0.55, 1.18
	>3 & ≤5	22	39	0.65	0.38, 1.10	0.63	0.36, 1.11
	>5 & ≤10	23	53	0.50	0.31, 0.82	0.56	0.33, 0.95
	>10	13	30	0.50	0.26, 0.96	0.39	0.18, 0.84
				p for trend 0.00002		p for trend 0.00009
NA-NSAIDS and 75 mg aspirin	0	1602	1852	1.00		1.00
	>0 & ≤5	23	50	0.53	0.32, 0.87	0.58	0.34, 1.00
	>5	25	59	0.49	0.30, 0.79	0.51	0.30, 0.86
				p for trend 0.0002		p for trend 0.002

↵* Adjusted for total energy intake, physical activity, smoking, total fibre intake, alcohol intake, sex, BMI, age and deprivation index.
↵† 1 mini aspirin pill=75 mg.