Table 3

Comparison of histological characteristics of patients with ACLF and CHD

Histological parameterACLF (n=54)CHD (n=48)P
Hepatic progenitor cells68±2960±36.50.2
Intermediate hepatocytes/CK714±1411.5±19.250.4
Intermediate hepatocytes /CK193.5±5.52±40.03
Proliferating hepatocytes /mib-11±31.5 ±3.250.3
>50% Parenchyma left44% (23/52)47% (22/47)0.6
Lobular bilirubinostasis†67% (35/52)85% (40/47)0.06

  • Ductular bilirubinostasis*

  • Focal/marked

  • 75% (39/52)

  • 29/10

  • 30% (14/47)

  • 13/1

0.0001
Cholangiolitis*64% (32/50)24% (11/46)0.0001
Iron overload28%22%0.6
Mallory bodies†70% (37/53)40% (19/47)0.004
Megamitochondria*84% (42/50)67% (31/46)0.03

  • Apoptotic bodies*

  • (a few/many)

  • 75% (38/51)

  • 67%/8% (34/4)

  • 50% (23/46)

  • 50%/0% (23/0)

0.01

  • Steatosis*

  • (2/3 grade)

  • 70% (37/53)

  • 13%/26% (7/14)

  • 36% (17/47)

  • 15%/4% (7/2)

0.004

  • Ballooning*

  • (a few/many)

  • 94% (50/53)

  • 57%/38% (30/20)

  • 78% (36/46)

  • 63%/5% (29/7)

0.008
Inflammation/lobular96% (49/51)87% (40/46)0.2
Satellitosis*63% (33/52)32% (15/47)0.002
Portal inflammation*94% (49/52)97% (44/46)0.6
Pericellular fibrosis*98% (49/50)78% (35/45)0.01
Ceroid macrophages†31% (15/49)16% (7/44)0.2
ASH mild23% (12/53)67% (32/48)0.0001
moderate49% (26/53)21% (10/48)0.001
severe25% (13/53)6% (3/48)0.01

  • Data are expressed as median±interquartile range (IQR) or percentage.

  • ↵* Presence;

  • ↵† marked.

  • ACLF, acute-on-chronic liver failure; ASH, alcoholic steatohepatitis; CHD, chronic hepatic decompensation.