Characteristics of the cases and controls
| Characteristics | Cases (N=742) | Controls (N=820) | ||
| Sex | ||||
| Male | 641 | (86.4) | 506 | (61.7) |
| Female | 101 | (13.6) | 314 | (38.3) |
| Age (years) | ||||
| 40–49 | 24 | (3.2) | 127 | (15.5) |
| 50–59 | 149 | (20.1) | 247 | (30.1) |
| 60–69 | 330 | (44.5) | 256 | (31.2) |
| 70–79 | 239 | (32.2) | 190 | (23.2) |
| Environmental risk factor | ||||
| Non-drinker | 63 | (8.5) | 341 | (41.6) |
| Ever-drinker (environmental risk) | 679 | (91.5) | 479 | (58.4) |
| Non-smoker | 103 | (13.9) | 422 | (51.5) |
| Ever-smoker (environmental risk) | 639 | (86.1) | 398 | (48.5) |
| Environmental risk No=0 | 36 | (4.9) | 252 | (30.7) |
| Environmental risk No=1 | 94 | (12.7) | 259 | (31.6) |
| Environmental risk No=2 | 612 | (82.5) | 309 | (37.7) |
| Genetic risk factor | ||||
| rs671 GG | 194 | (26.1) | 502 | (61.2) |
| rs671 AG/AA (genetic risk) | 548 | (73.9) | 318 | (38.8) |
| rs1229984 AA/AG | 591 | (79.6) | 776 | (94.6) |
| rs1229984 GG (genetic risk) | 151 | (20.4) | 44 | (5.4) |
| Genetic risk No=0 | 169 | (22.8) | 479 | (58.4) |
| Genetic risk No=1 | 447 | (60.2) | 320 | (39.0) |
| Genetic risk No=2 | 126 | (17.0) | 21 | (2.6) |
| Total risk | ||||
| Total risk No=0 | 15 | (2.0) | 115 | (14.0) |
| Total risk No=1 | 44 | (5.9) | 266 | (32.4) |
| Total risk No=2 | 187 | (25.2) | 348 | (42.4) |
| Total risk No=3 | 385 | (51.9) | 87 | (10.6) |
| Total risk No=4 | 111 | (15.0) | 4 | (0.5) |
Results are shown as number (%).
No: The environmental risk arising from smoking and alcohol consumption, both individually and in combination (risk=0, 1 or 2). Similarly, for the genetic risk of each factor of rs671 (AG/AA) and rs1229984 (GG) and their combined effect (risk=0, 1 or 2). Finally, we calculated the risk number for the four risk factors in comparison with subjects who had no risk factors to evaluate the accumulation of risk (risk=0, 1, 2, 3 or 4).