Table 1

Major causes of villous atrophy in adults

Pathological findings characteristic but not diagnostic
Coeliac disease*
Tropical sprue*
Adult-onset autoimmune enteropathy
Hypogammaglobulinaemia
Idiopathic AIDS enteropathy
Pathological findings that could be diagnostic
Eosinophilic gastroenteritis
Whipple disease
Abetalipoproteinaemia
Intestinal lymphoma
Collagenous sprue
Tuberculosis
Giardiasis*
Crohn's disease
Pathological findings that are non-specific
Small-bowel bacterial overgrowth*
Infectious enteritis*
Parasitic infestation*
Severe malnutrition
Small-bowel ischaemia
  • * More frequent causes.

  • AIDS, acquired immune deficiency syndrome.