Variable | HR n (95% CI) | p Value |
Training set | ||
Overall survival | ||
High risk miRNA signature | 3.046 (1.246 to 7.445) | 0.015 |
Tumour stage III and IV | 2.962 (1.895 to 4.631) | <0.0001 |
Relapse-free survival | ||
High risk miRNA signature | 3.337 (1.298 to 8.580) | 0.012 |
Tumour stage III and IV | 3.811 (1.495 to 9.715) | 0.001 |
Testing set | ||
Overall survival | ||
High risk miRNA signature | 2.891 (1.066 to 7.839) | 0.037 |
Tumour stage III and IV | 3.283 (1.278 to 8.438) | 0.014 |
Relapse-free survival | ||
High risk miRNA signature | 3.749 (1.472 to 9.550) | 0.006 |
Tumour stage III and IV | 3.444 (1.501 to 7.902) | 0.004 |
Validation set | ||
Overall survival | ||
High risk miRNA signature | 2.625 (1.059 to 6.504) | 0.037 |
Tumour stage III and IV | 3.350 (1.793 to 6.260) | 0.0002 |
Relapse-free survival | ||
High risk miRNA signature | 3.044 (1.086 to 8.532) | 0.034 |
Tumour stage III and IV | 3.312 (1.187 to 9.246) | 0.022 |
Note: Variables were selected with a stepwise selection method.