Patients' characteristics
| Characteristics | Normal control (n=9) | Inactive UC (n=18) | Active UC (n=28) | LGD (n=9) | HGD (n=7) | UC-CRC (n=11) | Sporadic CRC (n=14) |
| Gender | |||||||
| Male | 6 | 8 | 15 | 8 | 5 | 7 | 8 |
| Female | 3 | 10 | 13 | 1 | 2 | 4 | 6 |
| Mean age, years±SD | 39.6±17.8 | 43.3±13.5 | 41.2±15.6 | 41.0±10.5 | 39.7±10.7 | (56.1±16.5)* | (68.3±12.2)* |
| Mean duration of disease, years±SD | – | 16.8±10.2 | 11.0±9.5 | 14.8±5.5 | 14.6±9.4 | (22.3±5.8)† | NA |
| Extent of disease | |||||||
| Extensive colitis | – | 0 | 4 | 6 | 4 | 5 | 7 |
| Left-side colitis | – | 11 | 18 | 1 | 1 | 2 | 2 |
| Proctitis | – | 7 | 5 | 2 | 2 | 4 | 5 |
| Treatment | |||||||
| Aminosalicylates | – | 7 | 14 | 3 | 1 | 0 | – |
| Corticosteroids | – | 6 | 13 | 4 | 4 | 3 | – |
| Immunosuppressive agents | – | 6 | 11 | 4 | 4 | 7 | – |
| Biological agents | – | 3 | 1 | 1 | 1 | 0 | – |
| None | – | 3 | 6 | 0 | 2 | 4 | – |
| Pathological severity | |||||||
| Grade 0–1 | – | 18 | 0 | 6 | 1 | 2 | |
| Grade 2–5 | – | 0 | 25 | 0 | 3 | 6 | |
↵* The mean age of patients in the UC-CRC group (56.1±16.5) and sporadic CRC group (68.3±12.2) was significantly greater than those of other UC-CRC precursor groups (p<0.01).
↵† the mean duration of disease of patients with UC-CRC (22.3±5.8) was significantly longer than that of patients in other groups (p<0.01).
CRC, colorectal cancer; HGD, high-grade dysplasia; LGD, low-grade dysplasia; UC, ulcerative colitis.