Table 2

Assessment of response bias among returning participants who enrolled in 2002 or 2003

200420062008
ParticipantsTerminates*ParticipantsTerminates*ParticipantsTerminates*
Total n328010352572174323092006
Age at outbreak (mean±SD)36.4±22.132.3±21.837.4±22.132.5±21.837.9±22.132.6±21.8
Female gender: n (%)1889 (57.6)530 (51.2)1501 (58.4)918 (52.7)1379 (59.7)1040 (51.8)
Gastroenteritis during outbreak: n (%)2169 (66.1)712 (68.8)1706 (66.3)1175 (67.4)1528 (66.2)1353 (67.4)
Anxiety/depression: n (%)295 (9.0)110 (10.6)224 (8.7)181 (10.4)211 (9.1)194 (9.7)
Acute symptoms: n (%)
 Abdominal cramps1923 (58.6)628 (60.7)1509 (58.7)1042 (59.8)1354 (58.6)1197 (59.7)
 Fever886 (27.0)316 (30.5)686 (26.7)516 (29.6)612 (26.5)590 (29.4)
 Weight loss493 (15.0)181 (17.5)391 (15.2)283 (16.2)335 (14.5)339 (16.9)
 Blood in stools544 (16.6)193 (18.6)440 (17.1)297 (17.0)405 (17.5)332 (16.6)
Duration of diarrhoea
 <2 days140 (4.3)34 (3.3)113 (4.4)61 (3.5)108 (4.7)66 (3.3)
 2–3 days494 (15.1)155 (15.0)395 (15.4)254 (14.6)351 (15.2)298 (14.9)
 4–5 days341 (10.4)123 (11.9)272 (10.6)192 (11.0)254 (11.0)210 (10.5)
 6–7 days330 (10.1)117 (11.3)249 (9.7)198 (11.4)226 (9.8)221 (11.0)
 >7 days661 (20.2)212 (20.5)511 (19.9)362 (20.8)444 (19.2)429 (21.4)
Peak stool frequency
 1–3/day318 (9.7)114 (11.0)235 (9.1)197 (11.3)207 (9.0)225 (11.2)
 4–6/day663 (20.2)193 (18.6)527 (20.5)329 (18.9)468 (20.3)338 (16.8)
 7–10/day400 (12.2)159 (15.4)312 (12.1)247 (14.1)285 (12.3)274 (13.7)
 >10/day462 (14.1)144 (13.9)371 (14.4)235 (13.5)336 (14.6)270 (13.5)
  • Terminates include those who withdrew from the trial, were lost to follow-up or died.

  • * Includes deaths and withdrawals.

  • p<0.0001 vs participants.