Table 2

Distinct reactivity of sera from Il10–/– mice mice grown under germ-free conditions or in individually ventilated cages with electrophoretically resolved human tubulin preparations or recombinant FtsZ

Il10–/– mice (n=19)Reactivity of sera with electrophoretically resolvedDetection of p-ANCAs
C3H/HeJBir n=9 C57BL/6J n=10Human tubulin preparationsRecombinant FtsZ (E coli)
  • Germ-free conditions (n=9)

  • C3H/HeJBir n=4

  • C57BL/6J n=5

  • 0/9

  • -C3H/HeJBir n=4

  • -C57BL/6J n=5

  • 0/9

  • -C3H/HeJBir n=4

  • -C57BL/6J n=5

  • 0/9

  • -C3H/HeJBir n=4

  • -C57BL/6J n=5

  • Individually ventilated cages (n=10)

  • C3H/HeJBir n=5

  • C57BL/6J n=5

  • 8/10

  • -C3H/HeJBir n=3

  • -C57BL/6J n=5

  • 7/10

  • -C3H/HeJBir n=2

  • -C57BL/6J n=5

  • 8/10

  • -C3H/HeJBir n=3

  • -C57BL/6J n=5

  • p-ANCAs, perinuclear antineutrophil cytoplasmic antibodies.