Table 2

Regimens that have been used in the past but are generally not recommended as empiric treatment and treatments used as rescue treatment after failure of drug combinations in table 1

Regimen	Description (dosing, frequency, duration)
‘Legacy triple therapy’^* 14 days	Amoxicillin 1000 mg twice a day
	Clarithromycin 500 mg twice a day
	PPI (standard dose) twice a day
	or
	Amoxicillin 1000 mg twice a day
	Metronidazole 500 mg twice a day
	PPI (standard dose) twice a day
Rescue triple treatments 14 days	Amoxicillin 1000 mg twice a dayon days 1–5
	Third drug (eg, fluoroquinolone or rifabutin)^†
	PPI (standard dose) twice a day for all 10 days
Bismuth quadruple rescue treatment 14 days	Bismuth subcitrate or subsalicylate two tablets with meals and HS
	Tetracycline HCl 500 mg with meals and HS
	New drug (ie, furazolidone 100 mg three times a day)
	PPI (standard dose) twice a day
High dose PPI amoxicillin dual treatment 14 days	PPI (full dose) every 6 h
High dose PPI amoxicillin dual treatment 14 days	Amoxicillin 500 mg every 6 h

↵* See text for details. In most regions of the world success with the clarithromycin-containing triple regimen has fallen to <80% and is should be avoided as an empiric treatment. Tailored treatment for patients with susceptible strains can be used.
↵† Fluoroquinolone resistance is rapidly rising and it should not be used without prior susceptibility testing if a quinolone has been used previously for any indication or success with this type of treatment is known to be less than excellent locally.
HS, at bedtime; PPI, proton pump inhibitor.