Table 4

Correlations of intratumoral T cell (ITTC) levels with clinicopathological variables, microsatellite status and major histocompatibility complex (MHC) expression

ITTCp Value
LowHigh
SexMale76 (62.8%)134 (57.3%)0.314
Female45 (37.2%)100 (42.7%)
GradeWell9 (7.4%)13 (5.6%)0.883
Moderate91 (75.2%)177 (75.6%)
Poor18 (14.9%)39 (16.1%)
TNM stageI7 (5.8%)51 (21.8%)0.003*
II54 (44.6%)80 (34.2%)
III36 (30.5%)82 (35%)
IV20 (16.5%)19 (8.1%)
Vascular invasionAbsent49 (56.3%)127 (69.4%)0.041
Present38 (43.7%)56 (30.6%)
Site of primary tumourColon68 (63%)108 (50.7%)0.044
Rectum40 (37%)105 (49.3%)
MHC class INegative26 (21.5%)23 (9.9%)0.0002
Weak56 (46.3%)86 (36.9%)
Strong39 (32.2%)124 (53.2%)
Microsatellite instabilityMSI26 (22%)61 (27.5%)0.274
MSS92 (78%)161 (72.5%)
  • * χ2 test for trend.

  • Fisher exact test (two-tailed).