Serum parameters from normal animals, bile duct ligated (BDL) animals, thioacetamide administered (TAA) or TAA animals with amiloride (0.1 mg/kg b. w.) or canrenoate (10 mg/kg b. w.) pre-treatment
| Normal | BDL | TAA | TAA+amiloride pre-treatment | TAA+canrenoate pre-treatment | |
| Sodium (mmol/l) | 142±4.2 | 137±4.7 | 138±6.3 | 139±5.6 | 137±6.4 |
| Potassium (mmol/l) | 4.2±0.3 | 4.3±0.8 | 4.1±0.7 | 4.8±0.5 | 4.5±0.7 |
| Creatinine (mg/dl) | 0.2±0.1 | 0.3±0.1 | 0.4±0.1 | 0.4±0.2 | 0.3±0.2 |
| Bilirubin (mg/dl) | 0.2±0.1 | 8.3±0.5+ | 0.3±0.1 | 0.3±0.1 | 0.2±0.1 |
| Aspartate transaminase (U/l) | 45±8 | 98±17* | 132±12* | 124±18* | 129±15* |
| Alanine aminotransferase (U/l) | 34±5 | 75±12† | 139±5† | 127±5† | 135±5† |
| γ-Glutamyl transferase (U/l) | 1.3±0.4 | 21±1.7‡ | 18±1.9‡ | 10±1.5‡ | 21±1.7‡ |
| Alkaline phosphatase (U/l) | 165±23 | 172±40 | 183±40 | 187±40 | 195±40 |