Table 3

Pregnancy and fetal outcomes according to drug exposure groups

OutcomeGroup A (n=86)Group B (n=84)Group C (n=45)p Value
Live births*64.0% (53.9% to 74.1%)66.6% (56.5% to 76.7%)60.0% (45.7% to 74.3%)NS
Prematurity*21.8% (10.9% to 32.7%)16.0% (6.4% to 25.6%)14.8% (1.4% to 28.2%)NS§
Birth weight3114±654 (1495–4500)3088±645 (1250–4150)3289±465 (2300–4070)NS§
Low birth weight <2500 g*15.8%13.8%7.4%NS§
(6.3% to 25.3%)(5.0% to 22.6%)(0.0% to 17.3%)
No. of congenital abnormalities*240NS§
3.6% (0.0% to 8.5%)7.1% (0.5% to 13.7%)0.0% (0.0% to 0.0%)
  • Group A, women exposed to thiopurines; Group B, women receiving a drug other than thiopurines; Group C, women receiving no medication.

  • * % (95% CI).

  • Mean (g)±SD (range).

  • Two-by-two comparisons between groups according to the number of pregnancies (Fisher exact test).

  • § Two-by-two comparisons between groups according to the number of live births (Student test for birth weight; Fisher exact test for qualitative variables).

  • NS, non-significant.