Table 6

Details of the obstetric events

Treatment groupDrugs and trimesters of administration*IBDMother's age at delivery (years)Tobacco/alcoholObstetric historyBirth weight (g)Gestational age (weeks)Complications
Group AThiopurine (1/2/3)CD36No/noNone242033 weeks and 2 daysAspiration of meconium
Group AThiopurine (1/2/3) + clopidogrelCD29Yes/no10 elective abortionsNANAUmbilical artery thrombosis (therapeutic abortion performed)
Group AThiopurine (1/2/3) + 5-ASA (1)CD40No/noNone241039Minor haemolytic anaemia
Group B5-ASA (1/2/3)CD30No/noNone327040 weeks and 5 daysStrangulation of umbilical cord
Group B5-ASA (1/2/3)CD39No/no1 spontaneous abortion296038 weeks and 1 dayRespiratory arrest (mucus) and gastro-oesophageal reflux
Group B5-ASA (1/2/3)CD25No/noNone255035 weeks and 3 daysDelayed evacuation of meconium
Group BAnti-TNFα (1/2/3)CD33No/no1 spontaneous abortion190034 weeks and 4 daysApnoea in premature twin
Group B5-ASA (1/2/3) + ursodeoxycholic acidIBDU19No/noNone264039Neonatal jaundice and respiratory distress (aspiration)
Group CNoneCD27No/noNoneNA40Maternofetal infection (Streptococcus)
Group CNoneCD32No/noNone235037 weeks and 6 daysNeonatal jaundice
Group CNoneCD37Yes/noNoneNA30 weeks and 3 daysDeath on the seventh day of life (unknown aetiology)
  • * 1, first; 2, second; 3, third trimesters of pregnancy.

  • 5-ASA, 5-aminosalicylic acid; CD, Crohn's disease; IBD, inflammatory bowel disease; IBDU, inflammatory bowel disease unclassified; NA, not available; TNFα, tumour necrosis factor α.