Multivariate analyses of the simplified model with clinicopathological characteristics in cohort 2 (n=314) and cohort 3 (n=73)
| Variables | OS | RFS | |||
| HR (95% CI) | p Value | HR (95% CI) | p Value | ||
| Cohort 2 | |||||
| GGT (>54 U/l vs ≤54 U/l) | 1.78 (1.32 to 2.41) | 0.0002 | 1.53 (1.12 to 2.08) | 0.007 | |
| Tumour encapsulation (none vs complete) | 1.28 (0.96 to 1.71) | 0.096 | NA | ||
| Tumour differentiation (III–IV vs I–II) | 1.37 (1.00 to 1.87) | 0.049 | NA | ||
| Tumour size (>5 cm vs ≤5 cm) | 1.50 (1.11 to 2.01) | 0.007 | NA | ||
| Tumour number (multiple vs single) | 1.51 (1.05 to 2.17) | 0.028 | 1.57 (1.05 to 2.34) | 0.027 | |
| Vascular invasion (yes vs no) | 1.56 (1.07 to 2.27) | 0.020 | 1.48 (0.98 to 2.23) | 0.060 | |
| The simplified model | <0.0001 | <0.0001 | |||
| Moderate risk vs low risk | 1.85 (1.19 to 2.87) | 0.006 | 2.86 (1.67 to 4.88) | 0.0001 | |
| High risk vs low risk | 3.89 (2.52 to 6.01) | <0.0001 | 8.15 (4.78 to 13.90) | <0.0001 | |
| Cohort 3 | |||||
| GGT (>54 U/l vs ≤54 U/l) | 3.79 (1.18 to 12.14) | 0.025 | n.a. | ||
| Child–Pugh score (B vs A) | 4.15 (0.72 to 23.83) | 0.111 | n.a. | ||
| AFP (>20 ng/ml vs ≤20 ng/ml) | 1.84 (0.40 to 8.40) | 0.433 | 1.57 (0.46 to 5.36) | 0.472 | |
| Tumour size (>5 cm vs ≤5 cm) | 3.76 (1.08 to 13.06) | 0.037 | 2.44 (0.83 to 7.22) | 0.106 | |
| Vascular invasion (yes vs no) | 1.71 (0.57 to 5.14) | 0.336 | 2.32 (0.89 to 6.05) | 0.084 | |
| The simplified model | 0.017 | 0.001 | |||
| Moderate risk vs low risk | 2.19 (0.40 to 11.86) | 0.363 | 0.37 (0.37 to 10.42) | 0.425 | |
| High risk vs low risk | 7.21 (1.49 to 34.93) | 0.014 | 9.88 (2.17 to 45.11) | 0.003 | |
Multivariate analysis, Cox proportional hazards regression model. Variables were adopted for their prognostic significance by univariate analysis.
AFP, α-fetoprotein; GGT, γ-glutamyl transferase; NA, not applicable; OS, overall survival; RFS, relapse-free survival.