Table 2

Cytokine production (pg/ml) by cultured peripheral blood and lamina propria mononuclear cells

ResponderCytokinePeripheral bloodLamina propria
PrePostPrePost
T cell stimulationIL-13594±327265±108690±99*297±58*
IL-10523±176528±178139±58128±53
IFNγ4001±14164955±23341003±1851438±210
IL-4114±48119±53102±4130±10
IL-1739±1725±48±26±1§
Macrophage stimulationIL-642 466±498258 063±10 6051644±1471703±265
TNFα3439±4083250±4351012±172755±220
IL-12279±173196±7033±1067±25
Nonresponder
T cell stimulationIL-13350±116393±164542±83510±39
IL-10976±491574±206229±119437±236
IFNγ1770±5992587±16851688±6472700±1455
IL-4116±6953±3578±6924±22
IL-17191±16486±2770±3870±34§
Macrophage stimulationIL-6133 177±35 259117 952±35 8831861±8365125±3524
TNFα5298±17784429±1278885±4551346±456
IL-12165±6886±3026±620±13
  • * p=0.01 Resp LP T cell IL-13 pre versus post.

  • p=0.006 PB Post T cell IL-17 Resp versus Nonresp.

  • p=0.039 LP Pre T cell IL-17 Resp versus Nonresp.

  • § p=0.017 Post LP T cell IL-17 Resp versus Nonresp.

  • p=0.006 PB Pre Mac/APC IL-6 Resp versus Nonresp