Table 5

Types and prevalence of colorectal lesions in patients with biopsy proven NAFLD and controls

Colorectal lesions, n (%)Non-alcoholic steatohepatitis (N=49)Simple steatosis (N=86)Controls (N=181)p Value*p Valuep Value
Endoscopic polyp30 (61.2)47 (54.7)70 (38.7)0.0390.0600.56
Hyperplastic polyp13 (26.5)20 (23.3)28 (15.5)0.250.280.75
Adenomatous polyp25 (51.0)22 (25.6)39 (21.5)0.0010.870.005
 Right sided colon14 (28.6)18 (20.9)16 (8.8)0.0050.0320.43
 Left sided colon15 (30.6)9 (10.5)25 (13.8)0.0240.300.006
Polyp with villous architecture4 (8.2)5 (5.8)1 (0.6)0.0320.0470.73
Polyp with high grade dysplasia17 (34.7)11 (12.8)9 (5.0)<0.0010.0900.006
Advanced neoplasm17 (34.7)12 (14.0)10 (5.5)<0.0010.0720.011
 Right sided colon9 (18.4)9 (10.5)3 (1.7)0.0010.0170.27
 Left sided colon12 (24.5)4 (4.7)7 (3.9)<0.0010.830.002
Cancer1 (2.0)1 (1.2)1 (0.6)0.510.610.74
  • All comparisons were adjusted for age and gender. Advanced neoplasm was defined as presence of cancer, or adenomas with high grade dysplasia and/or villous architecture.

  • * NASH versus controls.

  • Simple steatosis versus controls.

  • NASH versus simple steatosis.

  • NAFLD, non-alcoholic fatty liver disease.