Table 6

Factors associated with colorectal adenomas and advanced neoplasm in 135 subjects with biopsy proven NAFLD

FactorsUnivariate analysisMultivariate analysis
OR (95% CI)p ValueOR (95% CI)p Value
Colorectal adenomas
 Non-alcoholic steatohepatitis (vs simple steatosis)3.03 (1.45 to 6.36)0.0034.89 (2.04 to 11.70)<0.001
 Age (years)1.03 (0.99 to 1.07)0.201.06 (1.00 to 1.12)0.071
 Male gender1.35 (0.66 to 2.76)0.421.85 (0.74 to 4.64)0.19
 Smoking0 (0–∞)1.0∞ (0–∞)1.0
 Colorectal cancer in first degree relatives1.95 (0.47 to 8.19)0.361.53 (0.29 to 8.21)0.62
 BMI (kg/m2)1.06 (0.97 to 1.16)0.171.07 (0.95 to 1.20)0.25
 Diabetes0.76 (0.38 to 1.55)0.460.72 (0.30 to 1.72)0.46
 Hypertension1.25 (0.62 to 2.55)0.531.67 (0.70 to 4.02)0.25
Advanced neoplasm
 Non-alcoholic steatohepatitis (vs simple steatosis)3.28 (1.40 to 7.65)0.0065.34 (1.92 to 14.84)0.001
 Age (years)1.06 (1.02 to 1.11)0.0081.07 (1.00 to 1.15)0.039
 Male gender1.82 (0.98 to 3.39)0.0591.52 (0.57 to 4.08)0.41
 Smoking2.24 (1.06 to 4.75)0.03617.64 (3.57 to 87.23)<0.001
 Colorectal cancer in first degree relatives0.66 (0.15 to 2.91)0.580.27 (0.03 to 2.83)0.27
 BMI (kg/m2)1.09 (1.03 to 1.16)0.0050.97 (0.85 to 1.11)0.70
 Diabetes1.75 (0.90 to 3.42)0.0990.79 (0.31 to 2.02)0.62
 Hypertension1.63 (0.86 to 3.10)0.141.21 (0.47 to 3.12)0.69
  • BMI, body mass index; NAFLD, non-alcoholic fatty liver disease.