Table 2

Median viral load (VL) drop in untreated spontaneous clearers and progressors

Spontaneous clearers (SC) (95% CI)ProgressorsHR* (95% CI)p Value
(PV) (95% CI)(FV) (95% CI)
Maximum HCV VL log10 (IU/ml) drop within 100 days from first positive PCR2.20 (1.65 to 5.03)0.03 (–0.33 to 0.23)0.58 (0.25 to 0.96)1.78 (1.45 to 2.18)<0.0001†
Maximum HCV VL log10 (IU/ml) drop within 200 days from first positive PCR3.46 (1.70 to 7.05)0.17 (–0.06 to 0.38)0.85 (0.45 to 1.77)1.68 (1.40 to 2.02)<0.0001†

  • ↵* HR represents change in hazard per log10 change in VL.

  • ↵† Highly significant p value <0.01.

  • HCV, hepatitis C virus.