Table 1

Adaptation of the induction regimen to the initial concentration of interleukin 12 (IL-12) in serum. Mifepristone (Mif) is administered daily by intraperitoneal injection. The first 2 days, a suboptimal dose of 125 μg/kg is given to all mice. The concentration of IL-12 is determined in the serum 10 h after the first Mif injection (first column on the left). Based on this information, the dose of Mif is established for days 3–5, and subsequently duplicated every 3 days

Initial IL-12 (ng/ml)Days of induction
3–56–89–11
<5100020004000Mif (μg/kg)
5–2050010002000
20–752505001000
>75125250500