Degree of diagnostic accuracy in HCC and non-malignant (NM) nodules (whole series)
| HCC (n=72) | NM (n=57) | Sensitivity | Specificity | PPV | NPV | Accuracy | Youden index | |
| All three positive | 26 | 0 | 36.1% | 100% | 100% | 55.3% | 64.3% | 0.36 |
| At least two positive | 58 | 0 | 80.6% | 100% | 100% | 80.3% | 89.2% | 0.81 |
| At least one positive | 70 | 9 | 97.2% | 84.2% | 88.6% | 96.0% | 91.5% | 0.81 |
| EZH2+/HSP70+ | 37 | 0 | 51.4% | 100% | 100% | 62.0% | 72.9% | 0.51 |
| EZH2+/GPC3+ | 37 | 0 | 51.4% | 100% | 100% | 62.0% | 72.9% | 0.51 |
| HSP70+/GPC3+ | 36 | 0 | 50.0% | 100% | 100% | 61.3% | 72.1% | 0.50 |
| EZH2+ | 56 | 4 | 77.8% | 93.0% | 93.3% | 76.8% | 84.5% | 0.71 |
| HSP70+ | 49 | 3 | 68.1% | 94.7% | 94.2% | 70.1% | 79.8% | 0.63 |
| GPC3+ | 49 | 2 | 68.1% | 96.5% | 94.2% | 70.5% | 80.6% | 0.65 |
NPV, negative predictive value; PPV, positive predictive value.