Table 5

Cox multivariate analyses of prognostic factors on overall survival

CharacteristicHR (95% CI)p Value
The First Affiliated Hospital cohort
 Sex (female vs male)1.303 (0.793 to 2.140)0.297
 α-Fetoprotein, ng/ml (≤20 vs >20)1.398 (0.912 to 2.141)0.124
 Tumour size, cm (≤5 vs >5)0.768 (0.437 to 1.348)0.358
 Tumour multiplicity (single vs multiple)1.711 (1.123 to 2.605)0.012
 Differentiation (well–moderate vs poor–undifferentiated)0.964 (0.518 to 1.792)0.907
 Stage (I–II vs III–V)1.818 (1.313 to 2.516)0.000
 Vascular invasion (no vs yes)2.609 (1.716 to 3.966)0.000
 Relapse (no vs yes)1.159 (0.806 to 1.667)0.426
 EZH2 (positive vs negative)2.305 (1.178 to 4.530)0.032
The Cancer Center cohort
 α-Fetoprotein, ng/ml (≤20 vs >20)2.083 (1.076 to 4.033)0.029
 Tumour size, cm (≤5 vs >5)1.627 (0.836 to 3.165)0.152
 Tumour multiplicity (single vs multiple)1.628 (0.843 to 3.144)0.147
 Stage (I–II vs III–IV)1.616 (0.862 to 3.031)0.134
 Vascular invasion (no vs yes)5.228 (1.486 to 18.390)0.000
 Relapse (no vs yes)1.163 (0.606 to 2.232)0.650
 EZH2 (positive vs negative)4.522 (1.020 to 20.054)0.047