Subjects characteristics according to LSM feasibility
| Characteristics | LSM failure n=51 | Unreliable LSM n=94 | Validated LSM n=1190 | p Value |
| Age, years | 60.1±9.8 | 58.4±9.5 | 57.7±8.8 | 0.15 |
| Women (%) | 56.9 | 48.9 | 39.5 | 0.01 |
| Smoking status (%): | ||||
| Non-smoker | 64.7 | 64.9 | 62.7 | 0.54 |
| Past smoker | 13.7 | 22.3 | 21.4 | |
| Current smoker | 21.6 | 12.8 | 16.0 | |
| Alcohol consumption, glasses/week | 1.7±2.7 | 1.4±2.4 | 2.1±4.0 | 0.46* |
| BMI, kg/m2 | 32.1±5.8 | 28.4±5.8 | 26.4±3.9 | <0.0001 |
| BMI (%): | ||||
| <25 kg/m2 | 15.7 | 21.3 | 37.1 | <0.0001 |
| 25–29.9 kg/m2 | 15.7 | 45.7 | 45.8 | |
| ≥30 kg/m2 | 68.6 | 33.0 | 17.1 | |
| Waist circumference, cm | 101.2±12.6 | 93.1±11.8 | 89.3±11.1 | <0.0001 |
| SBP, mm Hg | 137.4±16.5 | 132.6±15.6 | 131.8±15.4 | 0.05 |
| DBP, mm Hg | 82.0±8.8 | 80.2±9.9 | 79.8±9.5 | 0.28 |
| Fasting glucose, mmol/l† | 5.95 (5.61 to 6.30) | 5.64 (5.41 to 5.89) | 5.58 (5.51 to 5.65) | 0.10 |
| Triglycerides, mmol/l† | 1.35 (1.17 to 1.56) | 1.03 (0.93 to 1.15) | 1.13 (1.10 to 1.17) | 0.01 |
| HDL-cholesterol, mmol/l | 1.39±0.49 | 1.36±0.33 | 1.40±0.38 | 0.61 |
| GGT, UI/l† | 31.1 (25.4 to 38.1) | 23.9 (20.6 to 27.7) | 25.9 (24.9 to 27.1) | 0.12 |
| ALT, UI/l† | 23.6 (20.8 to 26.8) | 20.3 (18.5 to 22.3) | 22.5 (22.0 to 23.1) | 0.08 |
| Metabolic syndrome (%) | 47.1 | 20.2 | 20.3 | <0.0001 |
Data are means±SD or percentages unless otherwise specified.
↵* Test on ranks.
↵† Data are geometric means (95% Cl) due to skewed distribution.
ALT, alanine aminotransferase; BMI, body mass index; DBP, diastolic blood pressure; GGT, γ-glutamyltranspeptidase; HDL, high-density lipoprotein; LSM, liver stiffness measurement; SBP, systolic blood pressure.