Factors associated with LSM >8 kPa in univariate and multivariate analyses
| Univariate analysis | Multivariate analysis | |||||
| OR | 95% CI | p Value | OR | 95% CI | p Value | |
| Age ≥57 years (median) | 2.0 | 1.3 to 3.2 | 0.003 | 1.8 | 1.1 to 3.0 | 0.02 |
| Women | 0.5 | 0.3 to 0.7 | 0.002 | |||
| Smoking status (referrent non-smoker) | ||||||
| Ex-smoker | 1.7 | 1.0 to 2.8 | 0.05 | |||
| Smoker | 1.6 | 0.9 to 2.8 | 0.11 | |||
| Alcohol consumption (referrent 0 glass/day) | ||||||
| 1 glass/day | 1.4 | 0.7 to 2.9 | 0.39 | |||
| ≥2 glasses/day | 1.5 | 1.0 to 2.4 | 0.07 | |||
| BMI ≥30 kg/m2 | 3.6 | 2.3 to 5.7 | <0.0001 | 2.0 | 1.0 to 3.7 | 0.04 |
| Elevated waist circumference* | 2.6 | 1.7 to 4.1 | <0.0001 | 1.9 | 1.0 to 3.5 | 0.05 |
| Triglycerides >150 mg/dl | 2.0 | 1.2 to 3.2 | 0.004 | |||
| Diabetes† | 3.1 | 2.0 to 4.8 | <0.0001 | 1.7 | 1.0 to 2.8 | 0.03 |
| Hypertension‡ | 2.9 | 1.7 to 5.1 | 0.0002 | 1.7 | 0.9 to 3.1 | 0.08 |
| GGT ≥45 UI/l | 3.4 | 2.2 to 5.4 | <0.0001 | 1.7 | 1.0 to 2.9 | 0.04 |
| ALT ≥40 UI/l | 6.3 | 4.0 to 10.1 | <0.0001 | 4.2 | 2.4 to 7.2 | <0.0001 |
| Platelets <150 109/l | 3.7 | 1.2 to 11.3 | 0.03 | |||
↵* Highest quartile (>100 cm in men, >93 cm in women) versus Q1–Q3.
↵† Fasting glucose ≥6.1 mmol/l and/or antidiabetic medication.
↵‡ SBP ≥130 mm Hg and/or DBP ≥85 mm Hg and/or antihypertensive medication.
ALT, alanine aminotransferase; BMI, body mass index; GGT, γ-glutamyltranspeptidase; LSM, liver stiffness measurement.