Table 3

Serum lipid and lipoprotein concentrations and colorectal cancer risk by site

Quintiles*Continuous
Serum analytesQ1Q2Q3Q4Q5ptrend (median)For every SD increase
Colorectal cancer
Total cholesterol
 N cases/controls223/190219/195179/191176/199178/200975/975
 Crude RR1.000.99 (0.77 to 1.26)0.83 (0.65 to 1.07)0.83 (0.64 to 1.06)0.78 (0.60 to 1.01)0.030.95 (0.87 to 1.03)
 Adjusted RR1.000.90 (0.68 to 1.20)0.78 (0.58 to 1.05)0.74 (0.55 to 1.00)0.68 (0.50 to 0.92)<0.010.92 (0.84 to 1.01)
HDL-cholesterol
 N cases/controls226/178182/189169/171228/210161/218966/966
 Crude RR1.000.79 (0.62 to 1.01)0.78 (0.60 to 1.01)0.89 (0.69 to 1.14)0.65 (0.49 to 0.86)0.020.87 (0.80 to 0.95)
 Adjusted RR1.000.75 (0.56 to 1.01)0.78 (0.57 to 1.07)0.85 (0.62 to 1.15)0.54 (0.39 to 0.77)<0.010.83 (0.74 to 0.93)
LDL-cholesterol
 N cases/controls207/196208/200210/190183/190162/194970/970
 Crude RR1.001.00 (0.78 to 1.28)1.01 (0.79 to 1.30)0.87 (0.68 to 1.13)0.82 (0.63 to 1.07)0.090.95 (0.88 to 1.03)
 Adjusted RR1.000.94 (0.71 to 1.25)1.02 (0.76 to 1.37)0.86 (0.64 to 1.16)0.73 (0.54 to 0.99)0.040.93 (0.84 to 1.02)
Triglycerides
 N cases/controls168/194210/192169/189181/180211/184939/939
 Crude RR1.001.23 (0.95 to 1.60)1.01 (0.77 to 1.33)1.15 (0.88 to 1.52)1.30 (0.98 to 1.72)0.141.08 (0.99 to 1.18)
 Adjusted RR1.001.28 (0.95 to 1.73)1.02 (0.74 to 1.41)1.17 (0.85 to 1.63)1.19 (0.84 to 1.69)0.621.03 (0.92 to 1.15)
Apolipoprotein A-1
 N cases/controls196/167194/175171/193211/203180/214952/952
 Crude RR1.000.95 (0.74 to 1.22)0.86 (0.66 to 1.12)0.95 (0.73 to 1.24)0.78 (0.59 to 1.04)0.110.92 (0.84 to 1.00)
 Adjusted RR1.000.92 (0.68 to 1.25)0.73 (0.53 to 1.01)0.84 (0.61 to 1.16)0.67 (0.48 to 0.95)0.020.87 (0.79 to 0.97)
Apolipoprotein B
 N cases/controls185/185209/192178/190194/202184/181950/950
 Crude RR1.001.14 (0.88 to 1.48)0.97 (0.75 to 1.26)1.06 (0.81 to 1.37)1.04 (0.79 to 1.36)0.951.02 (0.94 to 1.11)
 Adjusted RR1.001.05 (0.77 to 1.42)0.93 (0.69 to 1.27)0.93 (0.69 to 1.27)0.94 (0.68 to 1.30)0.510.99 (0.90 to 1.09)
Colon cancer
Total cholesterol
 N cases/controls146/124139/124118/120100/124114/125617/617
 Adjusted RR1.000.88 (0.61 to 1.26)0.80 (0.55 to 1.15)0.66 (0.44 to 0.98)0.66 (0.45 to 0.98)0.020.88 (0.78 to 1.00)
HDL-cholesterol
 N cases/controls152/107112/117112/112146/13290/144612/612
 Adjusted RR1.000.72 (0.49 to 1.06)0.73 (0.49 to 1.10)0.83 (0.56 to 1.22)0.42 (0.28 to 0.65)<0.010.78 (0.68 to 0.89)
LDL-cholesterol
 N cases/controls125/120137/140130/113121/120101/121614/614
 Adjusted RR1.000.86 (0.60 to 1.24)1.04 (0.71 to 1.53)0.91 (0.61 to 1.34)0.72 (0.48 to 1.08)0.170.92 (0.81 to 1.05)
Triglycerides
 N cases/controls103/122144/134103/126110/110131/90591/591
 Adjusted RR1.001.30 (0.88 to 1.92)0.95 (0.62 to 1.45)1.17 (0.73 to 1.79)1.42 (0.91 to 2.31)0.231.08 (0.93 to 1.26)
Apolipoprotein A-1
 N cases/controls128/98128/114111/121104/138104/138600/600
 Adjusted RR1.000.93 (0.62 to 1.40)0.75 (0.50 to 1.15)0.80 (0.53 to 1.19)0.57 (0.37 to 0.88)<0.010.82 (0.72 to 0.94)
Apolipoprotein B
 N cases/controls121/121127/121113/119119/126119/112599/599
 Adjusted RR1.001.03 (0.69 to 1.53)0.91 (0.61 to 1.36)0.90 (0.60 to 1.34)0.99 (0.64 to 1.52)0.741.00 (0.88 to 1.15)
Rectal cancer
Total cholesterol
 N cases/controls77/6680/7161/7176/7564/75358/358
 Adjusted RR1.000.92 (0.57 to 1.51)0.67 (0.39 to 1.14)0.84 (0.51 to 1.38)0.68 (0.41 to 1.13)0.130.97 (0.83 to 1.12)
HDL-cholesterol
 N cases/controls74/7170/7257/5982/7871/74354/354
 Adjusted RR1.000.83 (0.51 to 1.36)0.88 (0.51 to 1.54)0.92 (0.54 to 1.58)0.79 (0.42 to 1.49)0.590.94 (0.76 to 1.15)
LDL-cholesterol
 N cases/controls82/7671/6080/7762/7061/73356/356
 Adjusted RR1.001.15 (0.71 to 1.88)1.05 (0.66 to 1.69)0.77 (0.48 to 1.25)0.79 (0.48 to 1.29)0.140.94 (0.81 to 1.09)
Triglycerides
 N cases/controls65/7266/5866/6371/7080/85348/348
 Adjusted RR1.001.38 (0.81 to 2.33)1.41 (0.81 to 2.47)1.30 (0.74 to 2.29)1.06 (0.60 to 1.88)0.700.97 (0.81 to 1.16)
Apolipoprotein A-1
 N cases/controls68/6966/6160/7282/7476/76352/352
 Adjusted RR1.000.98 (0.61 to 1.59)0.76 (0.45 to 1.27)0.97 (0.55 to 1.68)0.84 (0.46 to 1.54)0.570.96 (0.78 to 1.17)
Apolipoprotein B
 N cases/controls64/6482/7165/7175/7665/69351/351
 Adjusted RR1.001.25 (0.76 to 2.06)0.96 (0.58 to 1.59)1.07 (0.65 to 1.76)0.95 (0.57 to 1.59)0.640.99 (0.85 to 1.16)
  • * Quintile cut-off points were the same for all cancer sites. Total cholesterol: 211.5, 237.8, 259.5, 287.7 mg/dl; HDL-cholesterol: 43.3, 51.0, 58.8, 70.4 mg/dl; LDL-cholesterol: 131.9, 155.1, 175.2, 201.5 mg/dl; triglycerides: 79.7, 110.7, 145.3, 201.9 mg/dl; apolipoprotein A-1: 148.0, 165.0, 180.0, 202.0 mg/dl; apolipoprotein B: 98.0, 113.0, 125.0, 142.0 mg/dl.

  • Increases in 1 SD were the same for all cancer sites. Total cholesterol: 46.8 mg/dl; HDL-cholesterol: 16.6 mg/dl; LDL-cholesterol: 41.8 mg/dl; triglycerides: 104.5 mg/dl; apolipoprotein A-1: 32.0 mg/dl; apolipoprotein B: 27.0 mg/dl.

  • Conditioned on matching factors and adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish and alcohol, intake of fibre, energy from fat and energy from non-fat.

  • HDL, high density lipoprotein; LDL, low density lipoprotein.