Quintiles* | Continuous† | ||||||
Serum analytes | Q1 | Q2 | Q3 | Q4 | Q5 | ptrend (median) | For every SD increase |
Colorectal cancer | |||||||
Total cholesterol | |||||||
N cases/controls | 223/190 | 219/195 | 179/191 | 176/199 | 178/200 | 975/975 | |
Crude RR | 1.00 | 0.99 (0.77 to 1.26) | 0.83 (0.65 to 1.07) | 0.83 (0.64 to 1.06) | 0.78 (0.60 to 1.01) | 0.03 | 0.95 (0.87 to 1.03) |
Adjusted RR‡ | 1.00 | 0.90 (0.68 to 1.20) | 0.78 (0.58 to 1.05) | 0.74 (0.55 to 1.00) | 0.68 (0.50 to 0.92) | <0.01 | 0.92 (0.84 to 1.01) |
HDL-cholesterol | |||||||
N cases/controls | 226/178 | 182/189 | 169/171 | 228/210 | 161/218 | 966/966 | |
Crude RR | 1.00 | 0.79 (0.62 to 1.01) | 0.78 (0.60 to 1.01) | 0.89 (0.69 to 1.14) | 0.65 (0.49 to 0.86) | 0.02 | 0.87 (0.80 to 0.95) |
Adjusted RR‡ | 1.00 | 0.75 (0.56 to 1.01) | 0.78 (0.57 to 1.07) | 0.85 (0.62 to 1.15) | 0.54 (0.39 to 0.77) | <0.01 | 0.83 (0.74 to 0.93) |
LDL-cholesterol | |||||||
N cases/controls | 207/196 | 208/200 | 210/190 | 183/190 | 162/194 | 970/970 | |
Crude RR | 1.00 | 1.00 (0.78 to 1.28) | 1.01 (0.79 to 1.30) | 0.87 (0.68 to 1.13) | 0.82 (0.63 to 1.07) | 0.09 | 0.95 (0.88 to 1.03) |
Adjusted RR‡ | 1.00 | 0.94 (0.71 to 1.25) | 1.02 (0.76 to 1.37) | 0.86 (0.64 to 1.16) | 0.73 (0.54 to 0.99) | 0.04 | 0.93 (0.84 to 1.02) |
Triglycerides | |||||||
N cases/controls | 168/194 | 210/192 | 169/189 | 181/180 | 211/184 | 939/939 | |
Crude RR | 1.00 | 1.23 (0.95 to 1.60) | 1.01 (0.77 to 1.33) | 1.15 (0.88 to 1.52) | 1.30 (0.98 to 1.72) | 0.14 | 1.08 (0.99 to 1.18) |
Adjusted RR‡ | 1.00 | 1.28 (0.95 to 1.73) | 1.02 (0.74 to 1.41) | 1.17 (0.85 to 1.63) | 1.19 (0.84 to 1.69) | 0.62 | 1.03 (0.92 to 1.15) |
Apolipoprotein A-1 | |||||||
N cases/controls | 196/167 | 194/175 | 171/193 | 211/203 | 180/214 | 952/952 | |
Crude RR | 1.00 | 0.95 (0.74 to 1.22) | 0.86 (0.66 to 1.12) | 0.95 (0.73 to 1.24) | 0.78 (0.59 to 1.04) | 0.11 | 0.92 (0.84 to 1.00) |
Adjusted RR‡ | 1.00 | 0.92 (0.68 to 1.25) | 0.73 (0.53 to 1.01) | 0.84 (0.61 to 1.16) | 0.67 (0.48 to 0.95) | 0.02 | 0.87 (0.79 to 0.97) |
Apolipoprotein B | |||||||
N cases/controls | 185/185 | 209/192 | 178/190 | 194/202 | 184/181 | 950/950 | |
Crude RR | 1.00 | 1.14 (0.88 to 1.48) | 0.97 (0.75 to 1.26) | 1.06 (0.81 to 1.37) | 1.04 (0.79 to 1.36) | 0.95 | 1.02 (0.94 to 1.11) |
Adjusted RR‡ | 1.00 | 1.05 (0.77 to 1.42) | 0.93 (0.69 to 1.27) | 0.93 (0.69 to 1.27) | 0.94 (0.68 to 1.30) | 0.51 | 0.99 (0.90 to 1.09) |
Colon cancer | |||||||
Total cholesterol | |||||||
N cases/controls | 146/124 | 139/124 | 118/120 | 100/124 | 114/125 | 617/617 | |
Adjusted RR‡ | 1.00 | 0.88 (0.61 to 1.26) | 0.80 (0.55 to 1.15) | 0.66 (0.44 to 0.98) | 0.66 (0.45 to 0.98) | 0.02 | 0.88 (0.78 to 1.00) |
HDL-cholesterol | |||||||
N cases/controls | 152/107 | 112/117 | 112/112 | 146/132 | 90/144 | 612/612 | |
Adjusted RR‡ | 1.00 | 0.72 (0.49 to 1.06) | 0.73 (0.49 to 1.10) | 0.83 (0.56 to 1.22) | 0.42 (0.28 to 0.65) | <0.01 | 0.78 (0.68 to 0.89) |
LDL-cholesterol | |||||||
N cases/controls | 125/120 | 137/140 | 130/113 | 121/120 | 101/121 | 614/614 | |
Adjusted RR‡ | 1.00 | 0.86 (0.60 to 1.24) | 1.04 (0.71 to 1.53) | 0.91 (0.61 to 1.34) | 0.72 (0.48 to 1.08) | 0.17 | 0.92 (0.81 to 1.05) |
Triglycerides | |||||||
N cases/controls | 103/122 | 144/134 | 103/126 | 110/110 | 131/90 | 591/591 | |
Adjusted RR‡ | 1.00 | 1.30 (0.88 to 1.92) | 0.95 (0.62 to 1.45) | 1.17 (0.73 to 1.79) | 1.42 (0.91 to 2.31) | 0.23 | 1.08 (0.93 to 1.26) |
Apolipoprotein A-1 | |||||||
N cases/controls | 128/98 | 128/114 | 111/121 | 104/138 | 104/138 | 600/600 | |
Adjusted RR‡ | 1.00 | 0.93 (0.62 to 1.40) | 0.75 (0.50 to 1.15) | 0.80 (0.53 to 1.19) | 0.57 (0.37 to 0.88) | <0.01 | 0.82 (0.72 to 0.94) |
Apolipoprotein B | |||||||
N cases/controls | 121/121 | 127/121 | 113/119 | 119/126 | 119/112 | 599/599 | |
Adjusted RR‡ | 1.00 | 1.03 (0.69 to 1.53) | 0.91 (0.61 to 1.36) | 0.90 (0.60 to 1.34) | 0.99 (0.64 to 1.52) | 0.74 | 1.00 (0.88 to 1.15) |
Rectal cancer | |||||||
Total cholesterol | |||||||
N cases/controls | 77/66 | 80/71 | 61/71 | 76/75 | 64/75 | 358/358 | |
Adjusted RR‡ | 1.00 | 0.92 (0.57 to 1.51) | 0.67 (0.39 to 1.14) | 0.84 (0.51 to 1.38) | 0.68 (0.41 to 1.13) | 0.13 | 0.97 (0.83 to 1.12) |
HDL-cholesterol | |||||||
N cases/controls | 74/71 | 70/72 | 57/59 | 82/78 | 71/74 | 354/354 | |
Adjusted RR‡ | 1.00 | 0.83 (0.51 to 1.36) | 0.88 (0.51 to 1.54) | 0.92 (0.54 to 1.58) | 0.79 (0.42 to 1.49) | 0.59 | 0.94 (0.76 to 1.15) |
LDL-cholesterol | |||||||
N cases/controls | 82/76 | 71/60 | 80/77 | 62/70 | 61/73 | 356/356 | |
Adjusted RR‡ | 1.00 | 1.15 (0.71 to 1.88) | 1.05 (0.66 to 1.69) | 0.77 (0.48 to 1.25) | 0.79 (0.48 to 1.29) | 0.14 | 0.94 (0.81 to 1.09) |
Triglycerides | |||||||
N cases/controls | 65/72 | 66/58 | 66/63 | 71/70 | 80/85 | 348/348 | |
Adjusted RR‡ | 1.00 | 1.38 (0.81 to 2.33) | 1.41 (0.81 to 2.47) | 1.30 (0.74 to 2.29) | 1.06 (0.60 to 1.88) | 0.70 | 0.97 (0.81 to 1.16) |
Apolipoprotein A-1 | |||||||
N cases/controls | 68/69 | 66/61 | 60/72 | 82/74 | 76/76 | 352/352 | |
Adjusted RR‡ | 1.00 | 0.98 (0.61 to 1.59) | 0.76 (0.45 to 1.27) | 0.97 (0.55 to 1.68) | 0.84 (0.46 to 1.54) | 0.57 | 0.96 (0.78 to 1.17) |
Apolipoprotein B | |||||||
N cases/controls | 64/64 | 82/71 | 65/71 | 75/76 | 65/69 | 351/351 | |
Adjusted RR‡ | 1.00 | 1.25 (0.76 to 2.06) | 0.96 (0.58 to 1.59) | 1.07 (0.65 to 1.76) | 0.95 (0.57 to 1.59) | 0.64 | 0.99 (0.85 to 1.16) |
↵* Quintile cut-off points were the same for all cancer sites. Total cholesterol: 211.5, 237.8, 259.5, 287.7 mg/dl; HDL-cholesterol: 43.3, 51.0, 58.8, 70.4 mg/dl; LDL-cholesterol: 131.9, 155.1, 175.2, 201.5 mg/dl; triglycerides: 79.7, 110.7, 145.3, 201.9 mg/dl; apolipoprotein A-1: 148.0, 165.0, 180.0, 202.0 mg/dl; apolipoprotein B: 98.0, 113.0, 125.0, 142.0 mg/dl.
↵† Increases in 1 SD were the same for all cancer sites. Total cholesterol: 46.8 mg/dl; HDL-cholesterol: 16.6 mg/dl; LDL-cholesterol: 41.8 mg/dl; triglycerides: 104.5 mg/dl; apolipoprotein A-1: 32.0 mg/dl; apolipoprotein B: 27.0 mg/dl.
↵‡ Conditioned on matching factors and adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish and alcohol, intake of fibre, energy from fat and energy from non-fat.
HDL, high density lipoprotein; LDL, low density lipoprotein.