Table 2

Types and prevalence of colorectal lesions in NAFLD and control subjects

Colorectal lesions, n (%)Biopsy proven NAFLD (N=135)NAFLD by 1H-MRS (N=64)All NAFLD (N=199)Controls (N=181)p Value*p Valuep Value
Endoscopic polyp77 (57.0)28 (43.8)105 (52.8)70 (38.7)0.0130.940.057
Hyperplastic polyp33 (24.4)8 (12.5)41 (20.6)28 (15.5)0.160.320.50
Adenomatous polyp47 (34.8)22 (34.4)69 (34.7)39 (21.5)0.0630.150.043
 Right sided colon32 (23.7)15 (23.4)47 (23.6)16 (8.8)0.0040.0150.001
 Left sided colon24 (17.8)13 (20.3)37 (18.6)25 (13.8)0.610.430.51
Polyp with villous architecture9 (6.7)3 (4.7)12 (6.0)1 (0.6)0.0310.110.042
Polyp with high grade dysplasia28 (20.7)8 (12.5)36 (18.1)9 (5.0)0.0010.100.002
Advanced neoplasm29 (21.5)8 (12.5)37 (18.6)10 (5.5)0.0010.160.002
 Right sided colon18 (13.3)4 (6.2)22 (11.1)3 (1.7)0.0030.190.005
 Left sided colon16 (11.9)5 (7.8)21 (10.6)7 (3.9)0.0260.290.044
Cancer2 (1.5)02 (1.0)1 (0.6)0.451.00.65
  • All comparisons were adjusted for age and gender. Advanced neoplasm was defined as presence of cancer, or adenomas with high grade dysplasia and/or villous architecture.

  • * Patients with biopsy-proven NAFLD versus controls.

  • Patients with NAFLD by 1H-MRS versus controls.

  • All NAFLD patients versus controls.

  • 1H-MRS, proton-magnetic resonance spectroscopy; NAFLD, non-alcoholic fatty liver disease.