Characteristics of patients in the derivation and validation populations
| Derivation cohort n=860 | Validation cohort n=1892 | p Value | |
| Age (years), mean±SD | 54±11.6 | 51±11.2 | <0.01 |
| Gender (%) | |||
| Male | 471 (55) | 1032 (54) | 0.63 |
| Female | 389 (45) | 860 (46) | |
| Smoking (%) | <0.01 | ||
| Current* | 132 (15.6) | 269 (15.5) | |
| Ex-smoker | 263 (31.0) | 122 (7.0) | |
| Non-smoker | 452 (53.4) | 1342 (77.5) | |
| Alcohol consumption (%) | 157 (18.6) | 412 (23.9) | <0.01 |
| Diabetes mellitus (%) | 48 (5.6) | 113 (6.3) | 0.48 |
| Family history present for a first-degree relative (%) | 109 (12.7) | 286 (15.4) | 0.06 |
| Colon neoplasia (%) | 168 (18.5) | 353 (18.7) | |
| Cancer (%) | 9 (1.0) | 8 (0.4) | |
| Advanced neoplasia (%) | 39 (4.5) | 57 (3.0) | |
| Proximal neoplasia (%) | 66 (7.7) | 204 (10.8) | |
| Proximal advanced neoplasia (%) | 17 (2.0) | 24 (1.3) | |
↵* Current smoking denotes ≥1 pack of cigarettes/week.