Location, likelihood of metastasis and association with MEN1 in NETs21 22
Tumour | % Metastases | % MEN1 | Incidence per million per year |
Insulinoma | 10 | 5 | 1–2 |
Gastrinoma* | 60 | 25–40 | 1–2 |
Glucagonoma | 50–80 | 10 | 0.1 |
VIPoma | 40–70 | 5 | 0.1 |
Somatostatinoma* | 50–70 | 45 | <0.1 |
Non-syndromic | 60 | 20 | 1–2 |
↵* About half of cases arise in the duodenum.
MEN1, multiple endocrine neoplasia 1; NET, neuroendocrine tumour; VIPoma, vasoactive intestinal peptide-secreting tumour.