Risk of CRC and colorectal adenoma associated with the rs10936599 SNP
| Series | Ca11 | Ca12 | Ca22 | Co11 | Co12 | Co22 | MAF ca | MAF co | OR |
| VQ58 | 69 | 413 | 731 | 150 | 932 | 1407 | 0.23 | 0.25 | 0.894 |
| UK1/CORGI | 30 | 162 | 360 | 25 | 162 | 268 | 0.20 | 0.23 | 0.829 |
| Scotland1/COGS | 50 | 301 | 537 | 69 | 383 | 516 | 0.23 | 0.27 | 0.792 |
| APC adenomas/NBS | 75 | 558 | 936 | 152 | 936 | 1412 | 0.23 | 0.25 | 0.883 |
Genotype counts in cases (Ca) and controls (Co) are shown by sample series.
Allele 1=A, Allele 2=G.
Meta-analysis of the three colorectal cancer (CRC) case–control series gives OR 0.85 (95% CI 0.78 to 0.93), p=1.57×10−4, phet=0.442.
Note that only the data from the sample sets in this study are shown; the full genome-wide association study data can be obtained from Jeanclos et al.31
APC, Adenoma Prevention with Celecoxib Trial; MAF, minor allele frequency; NBS, National Blood Service; SNP, single nucleotide polymorphism.