Table 2

Risk of CRC and colorectal adenoma associated with the rs10936599 SNP

SeriesCa11Ca12Ca22Co11Co12Co22MAF caMAF coOR
APC adenomas/NBS7555893615293614120.230.250.883
  • Genotype counts in cases (Ca) and controls (Co) are shown by sample series.

  • Allele 1=A, Allele 2=G.

  • Meta-analysis of the three colorectal cancer (CRC) case–control series gives OR 0.85 (95% CI 0.78 to 0.93), p=1.57×10−4, phet=0.442.

  • Note that only the data from the sample sets in this study are shown; the full genome-wide association study data can be obtained from Jeanclos et al.31

  • APC, Adenoma Prevention with Celecoxib Trial; MAF, minor allele frequency; NBS, National Blood Service; SNP, single nucleotide polymorphism.