Associations between clinical characteristics of irritable bowel syndrome (IBS) and taxa
| Clinical parameters and physiological tests | Subset tested | Kendal correlation coefficient | p Value | Benjamini–Hochberg correction | |
| Phylum | |||||
| Proteobacteria | Mental component (SF-36) | IBS clusters 1 and 2 | 0.5 | <0.005 | <0.05 |
| Proteobacteria | Pain threshold (mm Hg) | IBS cluster 2 | 0.9 | <0.005 | <0.05 |
| Cyanobacteria | Satiety (GSRS) | Full IBS cohort | 0.37 | <0.005 | <0.05 |
| Cyanobacteria | GSRS total score | Full IBS cohort | 0.36 | <0.005 | <0.05 |
| Cyanobacteria | Bloating (GSRS) | Full IBS cohort | 0.36 | <0.005 | <0.05 |
| Euryarchaeota | Colonic transit time (days) | Full IBS cohort | 0.46 | <0.005 | <0.05 |
| Lentisphaerae | Constipation (GSRS) | Full IBS cohort | 0.53 | <0.0001 | <0.001 |
| Lentisphaerae | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.005 |
| Class | |||||
| Methanobacteria | Colonic transit time (days) | Full IBS cohort | 0.46 | <0.005 | <0.05 |
| Opitutae | Constipation (GSRS) | Full IBS cohort | 0.46 | <0.001 | <0.01 |
| Lentisphaeria | Constipation (GSRS) | Full IBS cohort | 0.53 | <0.0001 | <0.005 |
| Lentisphaeria | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.01 |
| Order | |||||
| Puniceicoccales | Constipation (GSRS) | Full IBS cohort | 0.46 | <0.001 | <0.01 |
| Methanobacteriales | Colonic transit time (days) | Full IBS cohort | 0.46 | <0.005 | <0.05 |
| Actinomycetales | Depression (HAD) | Full IBS cohort | −0.4 | <0.001 | <0.05 |
| Victivallales | Constipation (GSRS) | Full IBS cohort | 0.53 | <0.0001 | <0.005 |
| Victivallales | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.01 |
| Family | |||||
| Puniceicoccaceae | Constipation (GSRS) | Full IBS cohort | 0.46 | <0.001 | <0.05 |
| Peptostreptococcaceae | Constipation (GSRS) | Full IBS cohort | −0.36 | <0.005 | <0.05 |
| Methanobacteriaceae | Colonic transit time (days) | Full IBS cohort | 0.46 | <0.005 | <0.05 |
| Actinomycetaceae | Depression (HAD) | Full IBS cohort | −0.4 | <0.001 | <0.05 |
| Victivallaceae | Constipation (GSRS) | Full IBS cohort | 0.53 | <0.0001 | <0.005 |
| Victivallaceae | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.05 |
| Desulfohalobiaceae | Constipation (GSRS) | Full IBS cohort | 0.43 | <0.005 | <0.05 |
| Desulfohalobiaceae | Colonic transit time (days) | Full IBS cohort | 0.5 | <0.005 | <0.05 |
| Genus | |||||
| Odoribacter | Constipation (GSRS) | Full IBS cohort | 0.41 | <0.001 | <0.05 |
| Victivallis | Constipation (GSRS) | Full IBS cohort | 0.53 | <0.0001 | <0.01 |
| Victivallis | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.05 |
| Species | |||||
| Odoribacter splanchnicus | Constipation (GSRS) | Full IBS cohort | 0.43 | <0.0005 | <0.05 |
| Victivallis vadensis | Constipation (GSRS) | Full IBS cohort | 0.52 | <0.0001 | <0.01 |
| Victivallis vadensis | Constipation (GSRS) | Normal-like IBS | 0.77 | <0.0005 | <0.05 |
Significant results from analysis of subsets of IBS patients.
Values are correlations between the taxa and clinical parameters and physiological tests.
Pain thresholds are based on the rectal sensitivity test.
GSRS, Gastrointestinal Symptom Rating Scale; HAD, Hospital Anxiety and Depression Scale; SF-36, short form with 36 quality of life questions.