Combined analysis for discovery, NIDDK replication and Scottish validation cohorts showing association between RAC2 SNPs and Crohn's disease
| RAC2 gene | Chr 22 | Discovery Toronto cohort | NIDDK cohort | Scottish cohort | Combined analysis | ||||
| SNP | Position | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) |
| rs5756564 | 35 942 049 | 6.5×10−4 | 0.75 (0.64 to 0.88) | 5.0×10−2 | 0.84 (0.74 to 0.1.0) | 5.4×10−2 | 0.95 (0.83 to 1.10) | 4.0×10−4 | 0.85 (0.78 to 0.93) |
| rs6572 | 35 951 391 | 3.8×10−4 | 1.33 (1.13 to 1.57) | 5.0×10−1 | 1.04 (0.96 to 1.22) | 1.0×10−2 | 1.18 (1.03 to 1.36) | 5.0×10−5 | 1.19 (1.09 to 1.29) |
| rs9607431 | 35 959 884 | 8.5×10−5 | 1.57 (1.25 to 1.98) | 2.7×10−2 | 0.75 (0.58 to 0.96) | 5.4×10−1 | 1.06 (0.87 to 1.30) | 4.2×10−2 | 1.36 (1.01 to 1.25) |
| rs2239774 | 35 967 599 | 1.5×10−4 | 1.49 (1.21 to 1.84) | 4.4×10−2 | 0.78 (0.62 to 0.99) | 6.9×10−2 | 1.03 (0.86 to 1.25) | 5.0×10−2 | 1.12 (0.96 to 1.21) |
p Values are presented as uncorrected.
Combined analysis of the discovery, replication and validation cohorts (1790 patients with Crohn's disease and 2908 controls).