Increased abundance taxa associated with high Firmicutes:Bacteroidetes (FB) ratio irritable bowel syndrome (IBS)
| Controls | Normal-like IBS | IBS cluster 1 | IBS cluster 2 | p Value | |
| Phylum | |||||
| Firmicutes | 55.7 (50–71.9) | 56.1 (46.2–74) | 81.4 (74.8–87.7) | 80.4 (71–83.6) | <0.0001 |
| Actinobacteria | 0.75 (0.27–1.14) | 0.92 (0.15–1.88) | 5.38 (3.69–7.18) | 2.29 (1.64–2.55) | <0.0001 |
| Class | |||||
| Clostridia | 54.3 (46.6–67.3) | 54 (44.6–68.9) | 74.2 (71.5–81.7) | 74.5 (65.3–79.2) | <0.001 |
| Actinobacteria | 0.75 (0.27–1.14) | 0.92 (0.15–1.88) | 5.38 (3.69–7.18) | 2.29 (1.64–2.55) | <0.0001 |
| Erysipelotrichi | 0.8 (0.5–1.62) | 1.26 (0.76–1.37) | 2.17 (0.97–5.89) | 1.9 (1.53–4.51) | <0.01 |
| Order | |||||
| Clostridiales | 54.2 (46.4–67.1) | 53.7 (44.5–68.6) | 74 (71.4–81.7) | 74.2 (65.1–78.8) | <0.001 |
| Bifidobacteriales | 0.71 (0.27–1.03) | 0.9 (0.13–1.82) | 5.08 (2.98–7.14) | 1.55 (1.35–2.35) | <0.001 |
| Enterobacteriales | 0.0047 (0–0.0081) | 0.0067 (0.0037–0.011) | 0.036 (0.009–0.087) | 0.19 (0.13–0.5) | <0.001 |
| Actinomycetales | 0.008 (0.004–0.016) | 0.008 (0.005–0.016) | 0.03 (0.015–0.04) | 0.022 (0.02–0.047) | <0.001 |
| Coriobacteriales | 0.014 (0.007–0.052) | 0.013 (0.007–0.025) | 0.0435 (0.01–0.13) | 0.214 (0.161–0.308) | <0.01 |
| Bacillales | 0 (0–0) | 0 (0–0) | 0.004 (0–0.0067) | 0 (0–0.00195) | <0.01 |
| Family | |||||
| Incertae sedis XIV | 3.83 (2.89–8.18) | 5.12 (3.47–5.49) | 14.1 (7.18–20.3) | 4.73 (3.86–5.69) | <0.001 |
| Bifidobacteriaceae | 0.71 (0.27–1.03) | 0.9 (0.13–1.82) | 5.08 (2.98–7.14) | 1.55 (1.35–2.35) | <0.001 |
| Enterobacteriaceae | 0.0047 (0–0.0081) | 0.0067 (0.0037–0.0108) | 0.0362 (0.009–0.0868) | 0.194 (0.132–0.504) | <0.001 |
| Actinomycetaceae | 0.0076 (0.0036–0.0139) | 0.0077 (0.0034–0.0133) | 0.03 (0.0147–0.0381) | 0.0217 (0.018–0.0405) | <0.001 |
| Staphylococcaceae | 0 (0–0) | 0 (0–0) | 0.0034 (0–0.0055) | 0 (0–0) | <0.01 |
| Coriobacteriaceae | 0.014 (0.007–0.052) | 0.013 (0.007–0.025) | 0.0435 (0.01–0.13) | 0.214 (0.161–0.308) | <0.01 |
| Incertae sedis XII | 0 (0–0.0063) | 0.0101 (0–0.03) | 0 (0–0) | 0.0087 (0–0.0458) | <0.01 |
| Genus | |||||
| Papillibacter | 0.14 (0.0875–0.28) | 0.196 (0.14–0.282) | 0.542 (0.44–0.701) | 0.186 (0.156–0.255) | <0.0001 |
| Dialister | 0.029 (0–0.128) | 0.061 (0.0056–0.747) | 1.47 (0.782–4.07) | 0.441 (0.029–0.611) | <0.0001 |
| Bifidobacterium | 0.71 (0.27–1.02) | 0.894 (0.125–1.81) | 5.07 (2.97–7.12) | 1.54 (1.34–2.32) | <0.001 |
| Dorea | 0.566 (0.269–0.845) | 0.395 (0.315–0.56) | 1.71 (0.925–2.91) | 0.593 (0.433–1.03) | <0.001 |
| Blautia | 3.83 (2.88–8.18) | 5.12 (3.47–5.45) | 14.1 (7.18-20.3) | 4.69 (3.86-5.69) | <0.001 |
| Sporobacter* | 0.837 (0.246–1.65) | 0.805 (0.402–1.02) | 0.0615 (0.015–0.4) | 2.22 (1.59–2.5) | <0.001 |
| Actinomyces | 0.006 (0.001–0.014) | 0.0077 (0.0034–0.012) | 0.03 (0.015–0.036) | 0.019 (0.018–0.034) | <0.001 |
| Escherichia | 0 (0–0.0076) | 0.0036 (0.001–0.0084) | 0.0255 (0–0.0827) | 0.19 (0.0824–0.492) | <0.001 |
Significant results from the four group Kruskal–Wallis analysis.
This table represents the taxa that have higher abundance in the high FB ratio IBS clusters when compared with the control samples.
Values are shown as the median and associated IQR for the percentage of reads for the taxa in each group.
↵* Sporobacter has both highest and lowest values in the IBS clusters but is presented in this table as having its highest value in IBS cluster 2.