Gene | Fold change | Location | Function |
Upregulated genes | |||
APC | +1.41 | 5q21-q22 | Cell adhesion, inhibits proliferation |
BRMS1 | +1.14 | 11q13-q13.2 | Inhibits metastasis and tumour growth |
CDH11 | +1.36 | 16q22.1 | Involved in the metastatic process |
CD44 | +1.78 | 11p13 | Cell adhesion and stroma attachment |
COL4A2 | +1.80 | 13q34 | The component of extracellular matrix |
CST7 | +1.29 | 20p11.21 | Inhibits cysteine proteinase |
CTBP1 | +1.86 | 4p16 | Inhibits cell proliferation |
DENR | +1.75 | 12q24.31 | Promotes proliferation |
EPHB2 | +1.65 | 1p36.1-p35 | Signal transduction, promotes invasion |
ETV4 | +1.05 | 17q21 | Transcription factor, promotes proliferation |
EWSR1 | +1.07 | 22q12. | Transcription factor, promotes oncogenesis |
CD82 | +1.02 | 11p11.2 | Metastasis suppressor |
HPRT1 | +1.30 | Xq26.1 | Nucleotide metabolism |
HRAS | +1.65 | 11p15.5 | Promotes proliferation |
HTATIP2 | +1.20 | 11q13 | Positively regulates transcription |
IGF1 | +2.85 | 12q22-q23 | Promotes proliferation |
KISS1R | +1.14 | 19p13.3 | Suppresses metastasis |
RPSA | +1.04 | 3p22.2 | Participates in cell adhesion |
MCAM | +1.13 | 11q23.3 | Participates in cell adhesion |
METAP2 | +2.71 | 12q22 | Protein hydrolysate and modification |
MMP2 | +3.95 | 16q13-q21 | Decomposes, protein hydrolysate and promotes metastasis |
MMP7 | +1.66 | 11q21-q22 | Decomposes, protein hydrolysate and promotes metastasis |
MMP9 | +1.13 | 20q11.2-q13.1 | Decomposes, protein hydrolysate and promotes metastasis |
MTA1 | +3.83 | 14q32.3 | Promotes metastasis |
MYC | +1.72 | 8q24.12-24.13 | Promotes proliferation |
NF2 | +1.58 | 22q12.2 | Inhibits proliferation |
NME1 | +1.96 | 17q21.3 | Negatively regulates proliferation and participates in cell adhesion |
NME2 | +1.13 | 16q13 | Induces apoptosis |
NME4 | +1.56 | 16p13.3 | Inhibits proliferation |
RB1 | +1.17 | 13q14.2 | Negative regulation of cell reproduction |
SET | +1.29 | 9q34 | Inhibits histone acetylate |
SMAD4 | +1.85 | 18q21.1 | Cell signal transduction |
SRC | +1.03 | 20q12-q13 | Promotes proliferation |
SSTR2 | +1.68 | 17q24 | Inhibits proliferation |
SYK | +1.33 | 9q22 | Promotes proliferation |
TCF20 | +1.74 | 22q13.3 | Transcription factor |
TGF-β1 | +1.19 | 19q13.1 | Inhibits or promotes proliferation, promotes metastasis |
TIMP2 | +1.38 | 17q25 | Inhibits metastasis |
TIMP4 | +1.36 | 3p25 | Inhibits metastasis |
TNFSF10 | +1.24 | 3q26 | Induces apoptosis, inhibits proliferation |
TP53 | +1.47 | 17p13.1 | Induces apoptosis and cell differentiation, inhibits proliferation |
VEGFA | +1.41 | 6p12 | Promotes proliferation, metastasis; inhibits apoptosis |
B2M | +1.18 | 15q21-q22.2 | Immune response, MHCI receptor |
GAPDH | +1.93 | 12p13 | Glycometabolism |
ACTB | +1.02 | 7p15-p12 | Orm cytoskeleton |
Downregulated genes | |||
CCL7 | −1.18 | 16q13 | Promotes invasion and migration |
CDH1 | −1.40 | 16q22.1 | Inhibits tumour metastasis |
CDH6 | −1.11 | 5p15.1-p14 | Osteosis, cell adhesion |
CDKN2A | −1.22 | 9p21 | Negative regulation of cell cycle |
CHD4 | −1.13 | 12p13 | Chromatin assembly and modification |
CTNNA1 | −3.29 | 5q31 | Participates in cell adhesion |
CTSK | −1.97 | 1q21 | Protein hydrolysate |
CTSL1 | −1.18 | 9q21-q22 | Protein hydrolysate |
CXCR4 | −1.35 | 2q21 | Signal transduction, promotes invasion |
CXCL12 | −1.18 | 10q11.1 | Participates in cell adhesion |
FAT | −1.09 | 4q35 | Participates in cell adhesion |
FGFR4 | −1.46 | 5q35.1 | Promotes invasion |
FLT4 | −1.10 | 5q34-q35 | Promotes tumour metastasis |
FN1 | −1.11 | 2q34 | Participates in cell adhesion |
FXYD5 | −1.15 | 19q12-q13.1 | Negative regulation of cell adhesion |
GNRH1 | −1.18 | 8p21-p11.2 | Inhibits cell proliferation |
HGF | −1.87 | 7q21.1 | Participates in proteolysis, promotes proliferation |
HPSE | −1.15 | 4q21.3 | Hydrolyses protein |
IL18 | −1.43 | 11q22.2-q22.3 | Promotes cell proliferation |
IL1B | −1.59 | 2q14 | Inhibits or promotes proliferation |
IL8RB | −1.13 | 2q35 | Promotes proliferation |
ITGA7 | −1.19 | 12q13 | Participates in cell adhesion |
ITGB3 | −1.32 | 17q21.32 | Participates in cell adhesion |
KISS1 | −1.43 | 1q32 | Suppresses metastasis |
KRAS | −1.11 | 12p12.1 | Cell signal transduction, proliferation |
MDM2 | −1.15 | 12q14.3-q15 | Negative regulation of cell proliferation |
MET | −1.78 | 7q31 | Protooncogene, promotes cell proliferation |
MGAT5 | −1.29 | 2q21 | Promotes metastasis |
MMP3 | −1.03 | 11q22.3 | Decomposes, protein hydrolysate and promotes metastasis |
MMP10 | −1.40 | 11q22.3 | Protein hydrolysate, promotes metastasis |
MMP11 | −1.23 | 22q11.23 | Decomposes, protein hydrolysate and promotes metastasis |
MMP13 | −1.74 | 11q22.3 | Decomposes, protein hydrolysate and promotes metastasis |
MTSS1 | −1.69 | 8p22 | Inhibits metastasis and proliferation |
MYCL1 | −1.42 | 1p34.2 | Transcription factor, promotes proliferation |
NR4A3 | −3.47 | 9q22 | Transcription factor, promotes proliferation |
PLAUR | −1.60 | 19q13 | Activator of plasminogen |
PNN | −1.24 | 14q21.1 | Inhibits proliferation |
PTEN | −1.42 | 10q23.3 | Inhibits proliferation and metastasis |
RORB | −1.18 | 9q22 | Participates in regulation of transcription |
RPL13A | −1.56 | 19q13.3 | Protein metabolism, promotes proliferation |
SMAD2 | −1.85 | 18q21.1 | Cell signal transduction |
TIMP3 | −1.18 | 22q12.3 | Induces apoptosis, inhibits metastasis |
TRPM1 | −1.18 | 15q13-q14 | Calcium channels |
TSHR | −1.37 | 14q31 | Promotes proliferation |
CRC, colorectal carcinoma; EIF5A2, eukaryotic initiation factor 5A2.