Independent predictive factors of PPI failure in three groups of patients with gastro-oesophageal reflux symptoms (multivariate analysis)
| Factor | OR (95% CI) | p Value* |
| Whole population (n=100) | ||
| BMI ≤25 kg/m2 | 5.33 (1.88 to 15.07) | 0.002 |
| Functional dyspepsia | 5.61 (1.99 to 15.79) | 0.001 |
| No oesophagitis | 4.19 (1.00 to 17.64) | 0.050 |
| Patients with symptoms (n=85) | ||
| BMI ≤25 kg/m2 | 5.03 (1.66 to 15.23) | 0.004 |
| Functional dyspepsia | 4.46 (1.46 to 13.68) | 0.009 |
| Irritable bowel syndrome | 3.65 (1.03 to 12.98) | 0.044 |
| Patients with documented GORD (n=67) | ||
| Functional dyspepsia | 7.95 (2.00 to 31.60) | 0.003 |
| No oesophagitis | 6.96 (1.09 to 44.30) | 0.040 |
| Irritable bowel syndrome | 6.51 (1.51 to 28.08) | 0.012 |
| BMI ≤25 kg/m2 | 4.51 (1.17 to 17.38) | 0.029 |
Patients with documented GORD had 24 h oesophageal acid exposure >5% and/or positive SI/SAP.
↵* Logistic regression.
BMI, body mass index; GORD, gastro-oesophageal reflux disease; PPI, proton pump inhibitor.