Table 4

Main events during the 15-year follow-up

Mild-to-moderate 15-year CDSevere 15-year CDp Value
N279321
Close follow-up, %187 (67)208 (65)NS
Ever use of oral contraceptives, %54 (49)*82 (61)*NS
Any smoking, %121 (43)182 (57)0.001
Death related to CD, %023 (7)NA
Death unrelated to CD, %6 (2)6 (2)NS
Intestinal adenocarcinoma, %118<0.0001
Lymphoma, %11NS
Other malignancies, %2014NS
No. of years with active disease
 089 (32)4 (1)NA
 162 (22)6 (2)
 269 (25)11 (3)
 359 (21)17 (5)
 4–50108 (34)
 6–100134 (42)
 >10041 (13)
Changing behaviour, %
 B1 to B219 (12)*41 (18)*<0.001
 B1 to B318 (12)*56 (25)*
 B2 to B33 (7)*4 (11)*NS
Intestinal resection(s)61 (22)189 (59)NA
Delta PSHI0 (0–0)7 (0–21)<0.01
Establishment of a permanent stoma042 (14)*NA
Proctological procedure(s)20 (8)*75 (24)*<0.0001
  • All quantitative data are given as median (IQR).

  • * Per cent calculated in women of child-bearing age.

  • CD, Crohn's disease; NA, not applicable (item linked to the post hoc classification); NS, not significant percentage calculated in the appropriate subgroup of patients; PSHI, Post-Surgical Handicap Index.