Pkr−/− mice show reduced sensitivity to DSS-induced colitis
| Group | Treatment | Weight loss | Stool consistency | Rectal bleeding | DAI | Colon length (cm) | Histological score (0–12) |
| CTRL | Water | 0±0 | 0±0 | 0±0 | 0±0 | 8.83±0.58 | 0.00±0.00 |
| DSS | 2.8±1.47* | 3.6±0.80* † | 2.6±1.36 | 3.0±1.19* † | 6.04±0.30‡ § | 6.20±2.02§ ¶ | |
| Pkr−/− | Water | 0±0 | 0±0 | 0±0 | 0±0 | 9.00±0.73 | 0.88±0.25 |
| DSS | 0.2±0.40 | 0±0† | 0±0 | 0.07±0.13† | 7.42±0.56‡ § | 2.30±3.25¶ |
Pkr−/− and CTRL mice received cycles of 1% DSS for 7 days, followed by 7 days of water. The criteria for scoring the DAI are given in supplemental table 1.
↵* Statistically different from the water control group (ANOVA on Ranks followed by Dunn's test, p<0.05).
↵† Statistically different from the treatment control group (ANOVA on Ranks followed by Dunn's test, p<0.05).
↵‡ Statistically different from the treatment control group (two-way ANOVA followed by Tukey test, p<0.001).
↵§ Statistically different from the water control group (two-way ANOVA followed by Tukey test, p<0.001).
↵¶ Statistically different from the treatment control group (two-way ANOVA followed by Tukey test, p=0.010).
DSS, dextran sodium sulphate; DAI, Disease Activity Index; CTRL, control.