Author, year | Design | Primary outcome | Population | N | Detection (per-patient) (%) | p Value | Detection (per-polyp) | p Value | Comments | ||
CC | CAC | CC | CAC | ||||||||
Adenoma detection studies | |||||||||||
Hewett et al, 2010 | Cross-over (tandem), randomised order* | Adenoma miss rate | High-risk (referral: surveillance/screening) | 100 | 69 | 65 | N/A | 1.85† | 1.60† | N/A |
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Wijkerslooth et al, 2011 | Parallel, randomised | Adenoma detection | Average-risk (population-based screening) | 1380 | 29 | 29 | 0.96 | 0.50 | 0.52 | 0.83 | N/A |
Author, year | Design | Primary outcome | Population | N | Polyp detection (per-patient) | p | Polyp detection (per-polyp) | p | Comments | ||
CC | CAC | CC | CAC | ||||||||
Polyp detection studies (or other primary outcome) | |||||||||||
Tada et al, 1997 | Parallel, randomised | Caecal intubation time | High-risk (referral: FOBT+/surveillance) | 140 | N/A | N/A | N/A | 0.58 | 0.86 | <0.05 |
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Matsushita et al, 1998 | Cross-over (tandem), randomised order* | Polyp detection rate | High-risk (referral: polyps at previous barium enema) | 24 | N/A | N/A | N/A | 3.33† | 3.67† | N/A |
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Kondo et al, 2007‡ | Parallel, randomised | Caecal intubation rate | High-risk (referral) | 456 | 39.1% | 49.3% | 0.04 | 2.07† | 2.05† | N/A |
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Horiuchi et al, 2008 § | Tandem; fixed order; parallel randomisation after 1st colonoscopy | Caecal intubation time; number of adenomas | Patients with adenomas at 1st colonoscopy | 60 | N/A | N/A | N/A | 1.50† | 1.63† | N/A |
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Lee et al, 2009 | Parallel, randomised | Caecal intubation rate | High-risk (referral: symptoms/surveillance) | 1000 | 37.5% | 30.5% | 0.018 | 0.96 | 0.63 | 0.023 |
|
Harada et al, 2009 | Parallel, randomised | Caecal intubation time | High-risk (referral: symptoms/surveillance/screening) | 592 | 42.4% | 43.0% | 0.88 | 1.50† | 1.49† | N/A |
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Takeuchi et al, 2010¶ | Parallel, randomised | ‘Neoplasm’ detection rate | High-risk (referral: FOBT+/surveillance) | 274 | 55.6% | 59.6% | N/A | 1.19 | 1.72 | 0.21 |
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Tee et al, 2010 | Parallel, randomised | Caecal intubation time | High-risk (referral: symptoms/surveillance/screening) | 400 | 31.3% | 32.8% | 0.75 | 0.74† | 0.54† | N/A |
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Dai et al, 2010 | Parallel, randomised | Not specified | High-risk (referral) | 250 | 14.7%† | 15.7%† | N/A | 0.24† | 0.27† | N/A |
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Park et al, 2011 | Tandem; fixed order; parallel randomisation after 1st colonoscopy | Caecal intubation time; polyp miss rate | Patients being referred for removal of unresectable polyps | 329 | N/A | N/A | N/A | 3.4 | 2.7 | 0.003 |
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Horiuchi et al 2009 not displayed: tandem design with fixed order; randomisation after 1st (conventional) colonoscopy to either narrow-band imaging colonoscopy or colonoscopy with retractable extension device; because of design (absence of CC group), data extraction not possible.
↵* Tandem design; results of detected polyps derived from 1st colonoscopy; polyp miss rate (primary outcome) is displayed in the ‘comments’ column.
↵† Not reported in the study; derived from results.
↵‡ Randomised to three different arms. Only results from CC and CAC arm are displayed; polyp detection rate of the ‘short hood’ arm is not displayed.
↵§ Study was performed in two parts; first part non-randomised design (data not displayed), second part tandem design with fixed order in patients with adenomas at initial colonoscopy; randomisation in second part after 1st (conventional) colonoscopy to either conventional colonoscopy or colonoscopy with retractable extension device.
↵¶ Randomised to four different arms. Only results from CC and CAC arm are displayed; results from two autofluorescence imaging arms are not displayed. ‘Neoplasm’ was defined as an adenoma (low or high grade), non-invasive carcinoma, invasive carcinoma or carcinoid.
FOBT, faecal occult blood test.