Table 2

Characteristics of patients in the mild-to-moderate and severe Crohn's disease (CD) groups in 1995

AllMild-to-moderate 15-year CDSevere 15-year CDp Value*
N600279321
Age, years32.6 (26–42)36 (28–46)31 (24–39)<0.0001
Female, %356 (59)158 (57)198 (62)NS
Disease duration, years5.9 (2.3–10.0)9.4 (3.9–15.2)5.4 (2.1–10.3)<0.0001
IBD family history, %144 (24)67 (24)77 (24)NS
Extradigestive manifestations, %259 (43)113 (40)146 (45)NS
Disease location, %
 L1219 (36)107 (38)112 (35)
 L2171 (28)71 (25)100 (31)NS
 L3209 (35)100 (36)109 (34)
Upper tract involvement (L4), %62 (10)28 (10)53 (17)0.02
Rectal involvement, %229 (38)90 (32)139 (43)0.006
Perianal lesions, %258 (43)122 (44)136 (42)NS
Disease behaviour, %
 B1376 (63)152 (54)224 (70)0.0001
 B282 (14)46 (16)36 (11)
 B3143 (24)81 (29)61 (19)
Prior immunosuppressants, %166 (28)65 (23)101 (31)<0.0001
Prior intestinal resection, %265 (44)152 (54)113 (35)<0.0001
Permanent stoma, %34 (6)23 (8)11 (3)0.01
Post-Surgical Handicap Index20 (0–34)9 (0–25)0 (0–18)<0.0001
Obesity, %115 (19)57 (20)58 (18)NS
High educational level, %235 (39)126 (45)109 (34)0.005
  • All quantitative data are given as median (IQR).

  • * Comparisons between mild-to-moderate and severe 15-year CD groups.

  • IBD, inflammatory bowel disease; NS, not significant.