Table 2

Diagnostic accuracy for detection of hepatocellular carcinoma using one, two or three of the markers under study

Sensitivity (%)Specificity (%)PPV (%)NPV (%)LR+LR−
One marker
Two markers
Three markers
 At least 1 positive80.
 At least 2 positive60.010010055.6Inf0.400
 All 3 positive25.010010040.0Inf0.750
  • GPC3, glypican 3; GS, glutamine synthetase; HSP70, heat shock protein 70; Inf, Infinite; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.