Diagnostic accuracy for detection of hepatocellular carcinoma using one, two or three of the markers under study
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR− | |
|---|---|---|---|---|---|---|
| One marker | ||||||
| GPC3 | 57.5 | 95.0 | 95.8 | 52.8 | 11.500 | 0.447 |
| HSP70 | 57.5 | 85.0 | 88.5 | 50.0 | 3.833 | 0.500 |
| GS | 50.0 | 90.0 | 90.9 | 47.4 | 5.000 | 0.556 |
| Two markers | ||||||
| GPC3+HSP70 | 40.0 | 100 | 100 | 45.5 | Inf | 0.600 |
| GPC3+GS | 35.0 | 100 | 100 | 43.5 | Inf | 0.650 |
| HSP70+GS | 35.0 | 100 | 100 | 43.5 | Inf | 0.650 |
| Three markers | ||||||
| At least 1 positive | 80.0 | 70.0 | 84.2 | 63.6 | 2.667 | 0.285 |
| At least 2 positive | 60.0 | 100 | 100 | 55.6 | Inf | 0.400 |
| All 3 positive | 25.0 | 100 | 100 | 40.0 | Inf | 0.750 |
GPC3, glypican 3; GS, glutamine synthetase; HSP70, heat shock protein 70; Inf, Infinite; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.