Table 1

Pancreatic ductal epithelium disease in EL-Kras^G12D/pigment epithelium-derived factor (PEDF) null mice (Kras/PEDF−/−) compared with EL-Kras^G12D/PEDF wild type control mice (Kras/PEDF+/+)

Age	Acinar ductal metaplasia (%)^*		Cystic papillary neoplasms frequency^†		Pancreatic ductal adenocarcinoma (PDAC)^‡
Age	Kras/PEDF+/+	Kras/PEDF −/−	Kras/PEDF+/+	Kras/PEDF −/−	Kras/PEDF+/+	Kras/PEDF −/−
6–12 mo	27.3%	59.4%^§	4.6	15.1^§	0/10	0/9
13–22 mo	42.0%	83.5%^¶	11.6	35.6^§	0/14	6/41^**

↵* Per cent metaplastic acini per total number of acini counted in 3 medium power (20× objective) fields per animal.
↵† Mean number per 10 low power (10× objective) fields.
↵‡ Number of animals with PDAC/total number of animals.
↵§ p<0.05 compared to Kras/PEDF+/+.
↵¶ p<0.01 compared to Kras/PEDF+/+.
↵** Two out of the six animals with PDAC had metastases to the liver.