Factors associated with RVR and SVR in univariate and multivariate analysis
| Factor | RVR | SVR | ||
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Univariate analysis | ||||
| Age (years) | 0.97 (0.94 to 1.01) | 0.1410 | 0.96 (0.92 to 1.01) | 0.1088 |
| Sex (male/ female) | 0.86 (0.41 to 1.77) | 0.6738 | 0.82 (0.35 to 1.91) | 0.6383 |
| BMI (kg/m2) | 0.97 (0.89 to 1.05) | 0.4433 | 0.96 (0.87 to 1.05) | 0.3256 |
| Hypertension history (yes or no) | 0.54 (0.19 to 1.51) | 0.2395 | 0.37 (0.12 to 1.09) | 0.0714 |
| Baseline log10 HCV RNA | 0.44 (0.22 to 0.86) | 0.0173 | 0.48 (0.21 to 1.05) | 0.0668 |
| Fibrosis stage | 0.80 (0.52 to 1.21) | 0.2908 | 0.53 (0.33 to 0.87) | 0.0125 |
| Steatosis (yes or no)* | 0.77 (0.28 to 2.13) | 0.62 | 0.45 (0.14 to 1.45) | 0.18 |
| ALT (LN × ULN) | 1.00 (0.99 to 1.01) | 0.8644 | 1.00 (1.00 to 1.01) | 0.4914 |
| GGT (LN × ULN) | 0.99 (0.99 to 1.00) | 0.0709 | 0.99 (0.98 to 1.00) | 0.0060 |
| Triglycerides (mg/dl) | 1.00 (0.99 to 1.01) | 0.9204 | 1.00 (0.99 to 1.01) | 0.9750 |
| TC (mg/dl) | 1.01 (1.00 to 1.02) | 0.1008 | 1.01 (1.00 to 1.03) | 0.0784 |
| HDL cholesterol (mg/dl) | 1.00 (0.97 to 1.02) | 0.7683 | 0.99 (0.96 to 1.01) | 0.3426 |
| LDL cholesterol (mg/dl) | 1.01 (1.00 to 1.02) | 0.0905 | 1.02 (1.00 to 1.03) | 0.0269 |
| Glucose (mmol/l) | 1.15 (0.69 to 1.91) | 0.5892 | 1.05 (0.59 to 1.87) | 0.8644 |
| Insulin (mIU/l) | 1.01 (0.97 to 1.05) | 0.5307 | 1.00 (0.96 to 1.04) | 0.9709 |
| HOMA-IR >2 | 0.90 (0.43 to 1.86) | 0.7749 | 0.67 (0.29 to 1.56) | 0.3526 |
| q8 vs q12 | 1.06 (0.51 to 2.19) | 0.8797 | 1.27 (0.54 to 2.96) | 0.5848 |
| PEG α2a versus PEG α2b | 0.53 (0.28 to 1.03) | 0.0591 | 1.11 (0.48 to 2.60) | 0.8094 |
| Multivariate analysis | ||||
| Baseline log10 HCV RNA | 0.44 (0.22 to 0.86) | 0.0173 | ||
| Fibrosis stage | 0.47 (0.28 to 0.80) | 0.0050 | ||
| LDL (mg/dl) | 1.02 (1.00 to 1.04) | 0.0122 | ||
↵* In 73 patients with available data.
ALT, alanine aminotransferase; BMI, body mass index; GGT, γ-glutamyltranspeptidase; HCV, hepatitis C virus; HDL, high-density lipoprotein; HOMA-IR, homoeostatic model assessment-insulin resistance; LDL, low-density lipoprotein; LN, natural logarithm; PEG, peginterferon; q8h, every 8 h; q12h, every 12 h; RVR, rapid virological response; SVR, sustained virological response; TC, total cholesterol; ULN, upper limit of normal.