Table 3

Diagnostic accuracy for detection of hepatocellular carcinoma using one, two or three of the markers under study

Sensitivity (%)Specificity (%)PPV (%)NPV (%)LR+LR−
One marker
 GPC357.595.095.852.811.5000.447
 HSP7057.585.088.550.03.8330.500
 GS50.090.090.947.45.0000.556
Two markers
 GPC3+HSP7040.010010045.5Inf0.600
 GPC3+GS35.010010043.5Inf0.650
 HSP70+GS35.010010043.5Inf0.650
Three markers
 At least 1 positive80.070.084.263.62.6670.285
 At least 2 positive60.010010055.6Inf0.400
 All 3 positive25.010010040.0Inf0.750
  • GPC3, glypican 3; GS, glutamine synthetase; HSP70, heat shock protein 70; Inf, Infinite; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.