Table 1

Characteristics of interval cases after a negative colonoscopy during the preceding 1–10 years compared with cases with no previous colonoscopy during the same time interval

CharacteristicCases with interval cancerCases detected by screening, N (%)p Value*
Within <3 years, N (%)Within 3–10 years, N (%)Total, N (%)
Sex
 Men16 (45.7)18 (41.9)34 (43.6)287 (66.3)
 Women19 (54.3)25 (58.1)44 (56.4)146 (33.7)0.0001
Age
 <60 years6 (17.1)5 (11.6)11 (14.1)71 (16.4)
 60–69 years14 (40.0)20 (46.5)34 (43.6)167 (38.6)
 70–79 years9 (25.7)13 (30.2)22 (28.2)149 (34.4)
 80+ years6 (17.1)5 (11.6)11 (14.1)46 (10.6)0.55
Cancer site
 Caecum4 (12.1)8 (18.6)12 (15.8)45 (11.0)
 Ascending colon14 (42.4)10 (23.3)24 (31.6)74 (18.1)
 Right flexure, transverse colon2 (6.1)6 (14.0)8 (10.5)48 (11.7)
 Left flexure to sigmoid colon4 (12.1)11 (25.6)15 (19.7)139 (33.9)
 Rectum9 (27.3)8 (18.6)17 (22.4)104 (25.4)0.02
Stage
 I5 (14.3)7 (16.3)12 (15.4)178 (41.3)
 II13 (37.1)14 (32.6)27 (34.6)104 (24.1)
 III10 (28.6)19 (44.2)29 (37.2)127 (29.5)
 IV7 (20.0)3 (7.0)10 (12.8)22 (5.1)<0.0001
Grade
 G1and G221 (61.8)29 (72.5)50 (67.6)312 (79.2)
 G3 and G413 (38.2)11 (27.5)24 (32.4)82 (20.8)0.03
  • Numbers of cases with missing data: sex: 0 (0%), age: 0 (0%), cancer site: 25 (4.9%), stage: 2 (0.4%), grade: 43 (8.4%).

  • * For difference between all cases with interval cancer and cases detected by screening.

  • According to Union Internationale Contre le Cancer (I=T1/T2 N0 M0; II=T3/T4 N0 M0; III=any T N1/N2 M0; IV=any T any N M1).

  • G1=well differentiated, G2=moderately differentiated, G3=poorly differentiated, G4=undifferentiated.